AUTHOR=Abreu-Corrales Aymara , Velasco Ana , Cuesta-Gómez Alicia , Sánchez-González Juan Luis 

TITLE=Impact of reflex locomotion and the Bobath concept on clinical and biomolecular parameters in people with multiple sclerosis: study protocol for a randomized controlled trial

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1209477

DOI=10.3389/fneur.2023.1209477

ISSN=1664-2295

ABSTRACT=Introduction:   Multiple sclerosis (MS) is a progressive disease with a fluctuating and unpredictable course that to date has no curative treatment. One of its main characteristics is the variety of signs and symptoms that produce a high percentage of patients who present alterations in balance and gait during the development of the disease, decreased muscle strength, spasticity or decreased pimax, the therapy being rehabilitative therapy, and especially physiotherapy, a main way in the treatment of these alterations, through Reflex Locomotion and the Bobath Concept, as a form of kinesitherapy that activates the preorganized circuits of the central nervous system
Objective: To evaluate the Reflex locomotion and Bobath concept effects on balance, spasticity, reaction time, respiratory parameters and lacrimal biomolecular markers.
Methods and analysis: This is a randomized controlled trial on the effectiveness of two neurorehabilitation techniques in patients with multiple sclerosis conducted at the University of Salamanca. The research will take place at the Faculty of Nursing and Physiotherapy, University of Salamanca. The study will be conducted from June 2023 to June 2024. The Reflex locomotion group will receive individual sessions of therapy (n=27) and the Bobath concept group (n=27) will receive the same number of sessions. Both groups will receive 2 sessions per week for 12 months. The measurement variables will be the Berg Balance Scale, the Tardieu Scale, Cognitfit Program, Maximum Inspiratory Pressure and Lacrimal Biomarkers.
Ethics and dissemination: This study has been approved by the Ethics Committee University of Salamanca on March 2023 (ref: 896).
Trial registration number: NCT05558683
Limitations: The main limitations of this study are the selection and number of patients, delay in implementing the therapy within the initially scheduled period, inadequate sample collection and inadequate sample processing