AUTHOR=Blond Benjamin N. , Schindler Emmanuelle A. D. 

TITLE=Case report: Psychedelic-induced seizures captured by intracranial electrocorticography

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1214969

DOI=10.3389/fneur.2023.1214969

ISSN=1664-2295

ABSTRACT=Classic psychedelics are currently re-emerging as therapeutic agents with unique clinical benefits; however, it is also important to recognize the adverse effects of this drug class. While the risk of seizures with this drug class is known, the literature is lacking in detail. We present a case of psychedelic mushroom-induced seizures in a person with refractory right temporal lobe epilepsy implanted with a responsive neurostimulation system (RNS). A large increase in typical seizure frequency coincided with ingestion of a large dose of the mushrooms. This is the first reported case of electrographically confirmed seizures associated with classic psychedelic drug use. With the surge of research and movements towards clinical application of classic psychedelic compounds, the risk for drug-induced seizures should be considered, including such factors as history of epilepsy and drug dose and regimen.