AUTHOR=Chang Qi , Li Yaqiang , Xue Min , Yu Chuanqing , He Jiale , Duan Xun 

TITLE=Serum amyloid A is a potential predictor of prognosis in acute ischemic stroke patients after intravenous thrombolysis

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1219604

DOI=10.3389/fneur.2023.1219604

ISSN=1664-2295

ABSTRACT=Objectives: Inflammation shows a notable relationship to acute ischemic stroke's (AIS) occurrence and prognosis. However, existing research has confirmed that serum amyloid A (SAA) is an inflammatory biomarker. The aim of this paper was at investigating the association between SAA and the three-month clinical results of acute AIS patients after intravenous thrombolysis (IVT).The evaluation of AIS patients with complete medical records was carried out by prospectively investigating patients hospitalized in our department between January 2020 and February 2023. The SAA levels were examined with the use of immunosorbent assay kit that shows a relation to enzyme (Invitrogen Corp). Patients were dichotomized in favorable (mRS score of 0,1 or 2) and unfavorable (mRS score of 3, 4, 5, or 6) results with the use of the modified Rankin Scale (mRS).Results: 405 AIS patients who were subjected to IVT therapy were prospectively covered. To be specific, 121 (29.88%) patients had an unfavorable prognosis during the follow-up for three months. On that basis, patients achieving unfavorable results gained notably greater SAA levels ), P＜0.001) during hospitalization in comparison to patients with a better result. In the analysis with multiple variates, SAA was adopted to achieve the independent prediction of the three-month unfavorable clinical results of acute AIS patients after IVT[OR:2.874 (95% CI, 1.764-4.321), P＜0.001]. When the fundamental confounding factors were regulated, the odds ratio (OR) of unfavorable prognosis after AIS undergoing IVT therapy was 4.127 (95% CI =1.695-10.464, P = 0.032) for the maximum tertile of SAA in terms of the minimal tertile. With an AUC of 0.703 (95% CI, 0.649-0.757), SAA revealed a notably more effective discriminating capability in terms of CRP, NLR, EMR, and WBC. SAA as a predictor in terms of the prediction of three-month unfavorable results after AIS undergoing IVT therapy achieved the specificity and sensitivity of 84.45% and 77.23%, as well as an optimal cut-off value (COV) of 37.39.Conclusions: SAA level that is up-regulated during hospitalization is capable of serving as an effective marker in terms of the prediction of unfavorable three-month results in AIS patients after IVT.