AUTHOR=Ryu Dong-Woo , Han Kyungdo , Cho A-Hyun 

TITLE=Mortality and causes of death in patients with Parkinson's disease: a nationwide population-based cohort study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1236296

DOI=10.3389/fneur.2023.1236296

ISSN=1664-2295

ABSTRACT=Objective: Parkinson's disease (PD) is a neurodegenerative disease involving multiple systems, which can affect mortality. This study aimed to compare all-cause and causespecific mortality between people with PD and without PD Methods: This population-based prospective cohort study is based on Korean National Health Insurance Service data. The primary outcome was the hazard ratio (HR) of all-cause and cause-specific mortality for PD from 2010 to 2019. Cox proportional hazards regression was applied to calculate HRs under crude and three adjusted models with epidemiologic variables.Results: 8,220 PD patients and 41,100 age-and sex-matched control without PD were registered. 10-year mortality was 47.9% in PD patients and 20.3% in non-PD control. The mortality rate was higher in older and male participants. The leading cause of death in PD was nervous system diseases (38.73%), 97.1% of those were extrapyramidal and movement disorders, followed by circulatory diseases (15.33%), respiratory diseases (12.56%) and neoplasms (9.7%). PD contributed to an increased risk of all-cause death with an HR of 2.96 (95% CI = 2.84-3.08). HRs of death for PD were 3.07 (95% CI = 2.74-3.45) from respiratory diseases, 1.93 (95% CI = 1.75-2.13) from circulatory diseases, 2.35 (95% CI = 2.00-2.77) from external causes, and 2.69 (95% CI = 2.10-3.43) from infectious diseases.Conclusions: These results showed that PD related to a higher risk of mortality in all ages and sex. The leading causes of death in PD were nervous, circulatory, respiratory, infectious diseases, and external causes.