AUTHOR=Song Ruitong , Huang Wenqiao , Yang Jun , Tang Xueshan , Huang Yihua , Chen Yingying , Zhao Mukun , Hu Qiuming , Du Yi TITLE=Association of aquaporin-4 antibody-seropositive optic neuritis with vision-related quality of life and depression JOURNAL=Frontiers in Neurology VOLUME=Volume 14 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1265170 DOI=10.3389/fneur.2023.1265170 ISSN=1664-2295 ABSTRACT=Objective: Aquaporin-4 (AQP4) antibody-seropositive optic neuritis (AQP4-ON) is one of the most common types of optic neuritis in China. However, the association between AQP4-ON and vision-related quality of life (QoL) and depression remains poorly understood. In this cross-sectional study, 57 patients with optic neuritis were evaluated for their vision-related QoL using a Chinese version of the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) and assessed for depressive symptoms using a Chinese version of the Beck Depression Inventory-II (BDI-II). Data regarding participants' age, sex, visual acuity, and the number of recurrence events were gathered. Linear regression analysis was employed to investigate the relationships between AQP4-ON and vision-related QoL, as well as depression. Of the 57 included patients, 28 were AQP4-ON, and 29 were idiopathic optic neuritis (ION). AQP4-ON demonstrated a significant correlation with a decreased VFQ-25 composite score (Mean difference, -11.65 [95% CI, -21.61 to -1.69]; P =0.023) and an increased BDI-II score (Mean difference, 6.48 [95% CI, 0.25 to 12.71]; P =0.042) when compared to ION. The BDI-II score was correlated with the VFQ-25 composite score (Spearman ρ = -0.469; P < 0.001) but not with the visual acuity in the worse-seeing eye (Spearman ρ = 0.024; P = 0.860) or in the better-seeing eye (Spearman ρ = -0.039; P = 0.775), bilateral severe visual impairment (Spearman ρ = 0.039; P = 0.772) or the number of recurrence events (Spearman ρ = 0.184; P = 0.171). Conclusions: AQP4-positive optic neuritis is associated with a decline in vision-related quality of life as well as an increased likelihood of experiencing depression. It is crucial for clinicians to assess both vision-related QoL and depression in patients with AQP4-positive optic neuritis to provide patient-centered care.