AUTHOR=Fujita Takeshi , Seist Richard , Kao Shyan-Yuan , Soares Vitor , Panano Lorena , Khetani Radhika S. , Landegger Lukas D. , Batts Shelley , Stankovic Konstantina M. 

TITLE=miR-431 secreted by human vestibular schwannomas increases the mammalian inner ear’s vulnerability to noise trauma

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1268359

DOI=10.3389/fneur.2023.1268359

ISSN=1664-2295

ABSTRACT=This is a provisional file, not the final typeset article Results: Differentially expressed microRNAs included hsa-miR-431-5p (enriched in VS-PH) and hsa-miR-192-5p (enriched in VS-GH). Newborn mice receiving intracochlear injection of viral vectors over-expressing hsa-miR-431-GFP, hsa-miR-192-GFP, or GFP only (control) had similar hearing 6 weeks post-injection. However, after acoustic trauma, the miR-431 group displayed significantly worse hearing, and greater loss of synaptic ribbons per inner hair cell in the acoustically traumatized cochlear region than the control group.Conclusions: Our results suggest that miR-431 contributes to VS-associated hearing loss following cochlear stress. Further investigation is needed to determine whether miR-431 is a potential therapeutic target for SNHL.