AUTHOR=Yang Xia , Liu Qiong , Lai Ming-feng , Ma Xiao-hong , Hao Xiao-ting , Xu Jia-jun , Guo Wan-jun 

TITLE=Case report: Orthostatic leg tremor as the initial manifestation in a patient with metabotropic glutamate receptor-5 encephalitis without cortical dysfunction: complexities in identification and treatment

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1288075

DOI=10.3389/fneur.2023.1288075

ISSN=1664-2295

ABSTRACT=Objective: Metabotropic glutamate receptor 5 (mGluR5) encephalitis is such a rare type in autoimmune encephalitis that its' diagnosing remains a challenge.Case report: A 19-year-old female patient who initially presented anxiety and orthostatic leg tremor without cortical dysfunction. We found that mGluR5 antibodies of this patient were positive both in serum (1:1000) and in cerebrospinal fluid (1:32). After comprehensive intervention, the patient completely recovered at 18 months follow-up survey.Discussion: This report expands our knowledge of the possible presentations of mGluR5 encephalitis for early diagnosis, which makes it possible to prevent serious consequences and improve the prognosis.