AUTHOR=Lin Jie , Si Zhihua , Wang Aihua 

TITLE=Predictive value of ApoB/ApoA-I for recurrence within 1 year after first incident stroke

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1308442

DOI=10.3389/fneur.2023.1308442

ISSN=1664-2295

ABSTRACT=ApoB/ApoA-I ratio is a reliable indicator of cholesterol balance, particularly in the prediction of ischemic events risk. The aim of this study was to investigate the prognostic value of ApoB/ApoA-I for stroke recurrence within 1 year after the first incident. We retrospectively included patients who were first diagnosed with acute (<7 days after onset) ischemic stroke. Blood samples were collected on admission, and serum ApoB and ApoA-I concentrations were measured. We analyzed the relationship between ApoB/ApoA-I ratio and ischemic stroke recurrence within 1 year. A total of 722 patients with acute ischemic stroke were included, of whom 102 experienced stroke recurrence within 1 year, with a recurrence rate of 14.1%. Serum ApoB/ApoA-I concentrations on admission were higher in patients with stroke recurrence at 1 year compared with those with a good prognosis (P<0.001). The Kaplan-Meier survival curve revealed a significant difference in cumulative stroke recurrence rates across ApoB/ApoA-I tertiles (log-rank P value <0.001). A positive correlation between the ApoB/ApoA-I ratio and the risk of stroke recurrence within one year was demonstrated using Cox regression analysis, which remained significant after adjusting for traditional risk factors (hazard ratio [HR] 4.007, 95% confidence interval [CI] 1.661-9.666). This relationship was particularly strong in patients with LAA stroke (HR 4.955,. Subgroup analysis further revealed that a high ApoB/ApoA-I ratio was strongly associated with stroke recurrence regardless of whether patients had high or low LDL-C levels. ApoB/ApoA-I ratio, measured during the acute phase of the first stroke, was positively correlated with the risk of stroke recurrence within one year.