AUTHOR=Gong Xiuqun , Yu Chuanqing , Lu Zeyu , Wang Xia , Cai Qiankun , Cheng Xiaosi , Lu Jun 

TITLE=Residual inflammatory risk and vulnerable plaque in the carotid artery in patients with ischemic stroke

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1325960

DOI=10.3389/fneur.2024.1325960

ISSN=1664-2295

ABSTRACT=Objective: Inflammation is a central driver of atherogenesis and eventual plaque rupture. This study aimed to evaluate the association between residual inflammatory risk (RIR) and vulnerable plaque in the carotid artery in patients with ischemic stroke.: Patients with acute ischemic stroke were enrolled from January 2021 to July 2022. They were divided into four groups: RIR only (LDL-C <2.6 mmol/L and hsCRP ≥2 mg/L), residual cholesterol risk (RCR) only (LDL-C ≥2.6 mmol/L and hsCRP <2 mg/L), both risk or residual cholesterol and inflammatory risk (RCIR) (LDL-C ≥2.6 mmol/L and hsCRP ≥2 mg/L), and neither risk (LDL-C <2.6 mmol/L and hsCRP <2 mg/L). Vulnerable plaque was determined if low attenuated plaques CT value < 35 Hounsfield Units (HU) and remodeling index > 1.1 which indicated a positive remodeling.