AUTHOR=Wang Mingzhu , Peng Chengchao , Jiang Tingting , Wu Qiongfang , Li Danping , Lu Min 

TITLE=Association between systemic immune-inflammation index and post-stroke depression: a cross-sectional study of the national health and nutrition examination survey 2005–2020

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1330338

DOI=10.3389/fneur.2024.1330338

ISSN=1664-2295

ABSTRACT=Background: Less research has linked the Systemic Immune Inflammatory Index (SII) with poststroke depression (PSD). This study aims to look at any potential connections between SII and PSD. Methods: The National Health and Nutrition Examination Survey (NHANES), conducted in a population that embodied complete SII and stroke data from 2005 to 2020, was used to perform the current cross-sectional survey. A fitted smoothed curve was used to depict the nonlinear link between SII and PSD, and multiple linear regression analysis demonstrated a positive correlation between SII and PSD. Results: Multiple linear regression analysis showed that SII and PSD were markedly related [1.11(1.05,1.17)]. Interaction tests showed that the association between SII and PSD was not statistically different between strata, and age, sex, BMI, income poverty ratio, education level, smoking status, diabetes mellitus, coronary heart disease, and heart failure did not have a significant effect on this positive association (p > 0.05 for interaction). In addition, a nonlinear association between SII and PSD was found using a two-stage linear regression model.The results of our research support the existence of a significant positive correlation between SII levels and PSD. Further prospective trials are required to comprehend SII, which is for the PSD thoroughly.Stroke is the second leading cause of death globally and the leading cause of disability due to its high morbidity and mortality(1,2). It is widely known that a wide variety of functional impairments is prompted by stroke, such as cognitive impairment, motor dysfunction, and psychiatric disorders (3,4). Depression is the most common and severe neuropsychiatric complication after stroke(5), with a higher prevalence of post-stroke depression (PSD) of about 18-30%, and is considered an essential aspect affecting the recovery process of stroke patients(6). Patients with post-stroke depression are more prone to motor and cognitive dysfunction, thus decreasing the quality of life of patients (7) and hindering their reintegration into society and life(8,9). Further research is still underway to explore the etiology,