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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Autonomic Disorders
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1338153
This article is part of the Research Topic Gastrointestinal Autonomic Disorders View all 4 articles

Causality between major depressive disorder and functional dyspepsia: a two-sample Mendelian randomization study

Provisionally accepted
Yaming Du Yaming Du 1Rui Wang Rui Wang 1Xinzi Xu Xinzi Xu 1*Junli Wang Junli Wang 1*Wei Shao Wei Shao 2Guohua Chen Guohua Chen 1*
  • 1 Hubei University of Chinese Medicine, Wuhan, Hubei Province, China
  • 2 Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, Hubei Province, China

The final, formatted version of the article will be published soon.

    Background: To investigate the causal relationship between major depression and functional dyspepsia using two-sample Mendelian randomization. Methods: Data for major depression and functional dyspepsia were obtained from genome-wide association studies. We selected Single Nucleotide Polymorphisms (SNPs) strongly associated with severe depression. Mendelian randomization analysis was conducted using methods such as Inverse-Variance Weighted (IVW), MR-Egger, and Weighted Median Estimator (WME).Sensitivity analysis was performed to assess the robustness of the results.Results: A total of 31 eligible SNPs were identified as instrumental variables for major depression.IVW analysis indicated a positive causal relationship between the two conditions (β=0.328; SE=0.137; P=0.017), suggesting that severe depression increases the risk of functional dyspepsia (OR=1.389; 95% CI: 1.062-1.816). Sensitivity tests showed no evidence of heterogeneity or horizontal pleiotropy (P>0.05).MR analysis had shown that major depressive disorder is associated with an increased risk of functional dyspepsia.

    Keywords: Mendelian randomization, Major Depressive Disorder, functional dyspepsia, causal relationship, Disease risk

    Received: 14 Nov 2023; Accepted: 27 May 2024.

    Copyright: © 2024 Du, Wang, Xu, Wang, Shao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xinzi Xu, Hubei University of Chinese Medicine, Wuhan, 430065, Hubei Province, China
    Junli Wang, Hubei University of Chinese Medicine, Wuhan, 430065, Hubei Province, China
    Guohua Chen, Hubei University of Chinese Medicine, Wuhan, 430065, Hubei Province, China

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