AUTHOR=Du Yaming , Wang Rui , Xu Xinzi , Wang Junli , Shao Wei , Chen Guohua 

TITLE=Causality between major depressive disorder and functional dyspepsia: a two-sample Mendelian randomization study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1338153

DOI=10.3389/fneur.2024.1338153

ISSN=1664-2295

ABSTRACT=Background: To investigate the causal relationship between major depression and functional dyspepsia using two-sample Mendelian randomization. Methods: Data for major depression and functional dyspepsia were obtained from genome-wide association studies. We selected Single Nucleotide Polymorphisms (SNPs) strongly associated with severe depression. Mendelian randomization analysis was conducted using methods such as Inverse-Variance Weighted (IVW), MR-Egger, and Weighted Median Estimator (WME).Sensitivity analysis was performed to assess the robustness of the results.Results: A total of 31 eligible SNPs were identified as instrumental variables for major depression.IVW analysis indicated a positive causal relationship between the two conditions (β=0.328; SE=0.137; P=0.017), suggesting that severe depression increases the risk of functional dyspepsia (OR=1.389; 95% CI: 1.062-1.816). Sensitivity tests showed no evidence of heterogeneity or horizontal pleiotropy (P>0.05).MR analysis had shown that major depressive disorder is associated with an increased risk of functional dyspepsia.