AUTHOR=Fogarty Edward F. , Harch Paul G. 

TITLE=Case report: Dementia sensitivity to altitude changes and effective treatment with hyperbaric air and glutathione precursors

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1356662

DOI=10.3389/fneur.2024.1356662

ISSN=1664-2295

ABSTRACT=A 78-year-old male experienced waxing and waning of dementia symptoms with changes in altitude as he traveled from his home in the Rocky Mountains to lower elevations and back. To replicate the improvement in his symptoms with travel to lower elevations (higher pressure) the patient was treated with a near identical repressurization in a hyperbaric chamber using compressed air. With four one-hour treatments at 1.3 ATA and concurrent administration of lowdose oral glutathione amino acid precursors he recovered speech and improved activities of daily living. Regional broadcast media documented the novel recovery. Nosocomial COVID19 and withdrawal of sustaining hyperbaric therapy led to patient demise seven months after initiation of treatment. It is theorized that hyperbaric air therapy stimulated mitochondrial biochemical and physical changes that led to the clinical improvement.