AUTHOR=Hasani Fatemeh , Masrour Mahdi , Jazi Kimia , Ahmadi Payam , Hosseini Saba sadat , Lu Victor M. , Alborzi Amirmohammad TITLE=MicroRNA as a potential diagnostic and prognostic biomarker in brain gliomas: a systematic review and meta-analysis JOURNAL=Frontiers in Neurology VOLUME=Volume 15 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1357321 DOI=10.3389/fneur.2024.1357321 ISSN=1664-2295 ABSTRACT=This meta-analysis systematically examines the diagnostic and prognostic potential of microRNAs (miRNAs) in gliomas, representing over 50% of central nervous system tumors. Following PRISMA guidelines, a meticulous review identified 25 diagnostic and 99 prognostic studies meeting inclusion criteria. Results demonstrate that miRNAs exhibit exceptional diagnostic accuracy for gliomas, with a pooled sensitivity of 0.821, specificity of 0.831, and an impressive area under the curve (AUC) of 0.8791. Noteworthy miRNAs, such as miRNA-21, miRNA-128, and miRNA-210, emerge as consistent diagnostic biomarkers.The prognostic analysis, encompassing 11,518 glioma cases, underscores the significant association between miRNA dysregulation and adverse outcomes. An overall hazard ratio (HR) of 2.0221 for overall survival (OS) signals a heightened mortality risk with aberrant miRNA expression. Subgroup analyses based on specimen type validate miRNA prognostic value across diverse samples. Key miRNA-222 is identified as a robust predictor of poor prognosis in gliomas.While providing critical insights, our study acknowledges potential publication bias and heterogeneity as challenges. These findings emphasize the need for standardized diagnostic and prognostic panels, accounting for tumor grade and population diversity. In conclusion, miRNAs emerge as versatile and valuable biomarkers, offering significant clinical implications for glioma diagnosis and prognosis, thereby advancing precision medicine in neuro-oncology.