AUTHOR=Chen Mingzhu , Hong Zhou , Shi Haicun , Wen Chunmei , Shen Yuan 

TITLE=Stiff-person syndrome in association with Hashimoto’s thyroiditis: a case report

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1360222

DOI=10.3389/fneur.2024.1360222

ISSN=1664-2295

ABSTRACT=Stiff Person Syndrome (SPS) is a rare neurological disorder characterized by chronic and progressive axial muscle rigidity and paroxysmal painful muscle spasms. The present case study described a SPS patient (increased anti-GAD65 antibody in serum and cerebrospinal fluid), with co-occurring Hashimoto’s thyroiditis and decreased C3 complement levels. The clinical presentation, diagnostic approach, and treatment employed for this unique case were comprehensively described in detail. In this case, we comprehensively presented a case of SPS with co-occurring Hashimoto’s thyroiditis with associated decrease in serum C3 complement as well a discussion on the current data on this topic.