AUTHOR=Choi Maxwell C. Y. , Law Tiffany H. P. , Chen Sirong , Cheung William S. K. , Yim Carmen , Ng Oliver K. S. , Au Lisa W. C. , Mok Vincent C. T. , Woo Peter Y. M. 

TITLE=Case Report: Taxifolin for neurosurgery-associated early-onset cerebral amyloid angiopathy

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1360705

DOI=10.3389/fneur.2024.1360705

ISSN=1664-2295

ABSTRACT=Cases of iatrogenic cerebral amyloid angiopathy (CAA) have been increasingly reported recently, particularly those associated with neurosurgery. Preclinical studies have shown taxifolin to be promising in treating CAA. We describe a young 42-year-old gentleman, with a history of childhood traumatic brain injury that required a craniotomy for hematoma evacuation, who presented with recurrent lobar intracerebral hemorrhage (ICH) decades later that was histologically confirmed to be CAA. Serial 11 C-Pittsburgh compound B positron emission tomography ( 11 C-PiB-PET) imaging showed 24% decrease in global SUVR at ten months after taxifolin use compared to six months. During this period, the patient experienced clinical improvement with improved consciousness between recurrent lobar ICH, which may be partly attributable to the potential amyloid-β (Aβ) clearing effect of taxifolin. However, this effect seems to be diminished at fifteen months with a 22.4% decrease in SUVR compared to six months. Therefore, CAA should be considered in young patients presenting with recurrent lobar ICH with a history of childhood neurosurgery, and serial 11 C-PiB-PET scans warrant further validation as a strategy of monitoring treatment response in CAA to candidate Aβclearing therapeutic agents like taxifolin.