AUTHOR=Li Liang , Liang Zhihui , Lin Cong , Cui Bao , Jia Qiong 

TITLE=Efficacy and safety of 3-month dual antiplatelet therapy in patients after mechanical thrombectomy for acute ischemic stroke: a retrospective study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1374093

DOI=10.3389/fneur.2024.1374093

ISSN=1664-2295

ABSTRACT=Background: Mechanical thrombectomy (MT) is one of the effective treatment methods for acute ischemic stroke (AIS), which requires a period of dual antiplatelet therapy (DAPT) after endovascular treatment. The purpose of this study is to compare the efficacy and safety of 3-month DAPT and 1-month DAPT in AIS patients receiving mechanical thrombectomy through a retrospective study.: AIS patients who received MT from May 2018 to March 2023 were divided into a 1month group (1-M group) and a 3-month group (3-M group) according to the duration of DAPT after MT. The primary outcome was mRS score at 90 days. Secondary outcomes included a good prognosis (mRS score of 0-2) at 90 days post-surgery, 6-month mortality, recurrence of cerebral infarction, Barthel's index, Montreal Cognitive Assessment (MoCA) score, and incidence of symptomatic intracranial hemorrhage (sICH) during hospitalization.Result: A total of 147 patients with AIS were included in final analysis, with 78 patients in 1-M group and 69 patients in 3-M group. The baseline and neurological characteristics were comparable between two groups. At 3-month follow-up, a total of 61 patients had an mRS of 0-2 at 90 days, with an average mRS of 3.3 ± 0.9 for all patients. There was no statistically significant difference in mRS between the two groups of patients at 90 days (P>0.05). There was no statistically significant difference in the mortality rate and incidence of sICH between the two groups of patients during the 6-month follow-up period (P>0.05), but the recurrence rate of AIS in the 3-M group was lower than that in the 1-M group (P<0.05). The Barthel improvement and MoCA improvement of patients in the 3-M group were higher than those in the 1-M group at 6 months, but not statistically different (P>0.05).For AIS patients undergoing mechanical thrombectomy, compared to 1-month DAPT, 3-month DAPT can reduce the recurrence rate of IS during a 6-month follow-up period, without increasing mortality and risk of cerebral hemorrhage.