AUTHOR=Rodríguez-Méndez Axel Abel , Briseño-Ramírez Jaime , Rivas-Ruvalcaba Francisco Javier , Solis-Estrada Javier , Alcázar-García Liliana Berenice , Díaz-Ramírez Karely , Lira-Jaime Gabriela , Sánchez-Román Edgar Javier , Zúñiga-Ramírez Carlos 

TITLE=Clinical predictors for mechanical ventilation assistance in Guillain-Barré syndrome

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1385945

DOI=10.3389/fneur.2024.1385945

ISSN=1664-2295

ABSTRACT=Background: Guillain-Barré syndrome (GBS) frequently leads to respiratory failure and autonomic dysfunction, resulting in approximately one-third of patients requiring mechanical ventilation.

Objective: To identify clinical predictors for mechanical ventilation in patients with GBS. 

Methods: This research was conducted from 2010 to 2021 using registries from a tertiary hospital in an upper middle-income Latin American country. Participants were categorized into two groups based on their ventilation status. Demographic data were collected, and independent predictors of the need for mechanical ventilation were determined through multivariate logistic regression analysis.

Results: Dysautonomic events occurred in 36% of the patients, with 17% requiring mechanical ventilation; the average duration of intubation was 1.16 ± 3.18 days. The multivariate analysis indicated that bulbar dysfunction significantly increased the likelihood of requiring mechanical ventilation by 19-fold (OR 18.67, 95% CI 5.85-59.42), followed by ophthalmoplegia, which increased the likelihood sixfold (OR 5.68, 95% CI 1.28-25.19).

Conclusions: Bulbar dysfunction, dysautonomia, and lower Medical Research Council (MRC) scores were significant predictors of the need for mechanical ventilation in hospitalized GBS patients. These findings support the necessity for close monitoring and early intensive care unit (ICU) admission for patients identified at risk.