AUTHOR=Huang Jingxuan , Deng Aiping , Bai Yunshuang , Li Chunyu , Shang Huifang 

TITLE=Alzheimer’s disease and oral manifestations: a bi-directional Mendelian randomization study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1391625

DOI=10.3389/fneur.2024.1391625

ISSN=1664-2295

ABSTRACT=Background: Epidemiological studies have provided evidence suggesting an association between Alzheimer's disease (AD) and various oral manifestations. However, conflicting conclusions have been drawn, and whether a causal association truly exists remains unclear.In order to investigate the potential causal association between AD and prevalent oral diseases, we conducted a bi-directional two-sample Mendelian randomization analysis based on summary statistics from genome-wide association studies of AD (N=63,926), as well as mouth ulcer (N=461,103), oral cavity cancer (N=4,151), and periodontal disease (N=527,652).We identified that one standard increase in the risk of AD was causally associated with a reduced risk of oral cavity cancer (OR=0.76, 95% CI: 0.63-0.92, P=3.73E-03). In the opposite direction, oral conditions were not causally associated with risk of AD.The present findings contributed to a better understanding of the correlation between AD and oral conditions, specifically oral cavity cancer. These results also identified new avenues for exploring the underlying mechanisms of oral cavity cancer.