AUTHOR=Saporito Gennaro , Sucapane Patrizia , Bruno Federico , Catalucci Alessia , Masciocchi Carlo , Pistoia Maria Letizia , Splendiani Alessandra , Ricci Alessandro , Di Cesare Ernesto , Marini Carmine , Mazza Monica , Totaro Rocco , Pistoia Francesca 

TITLE=Cognitive safety of focused ultrasound thalamotomy for tremor: 1-year follow-up results of the COGNIFUS part 2 study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1395282

DOI=10.3389/fneur.2024.1395282

ISSN=1664-2295

ABSTRACT=Introduc4on: In the COGNIFUS (COGNi4ve in Focused UltraSound) study, we examined the 6-month cogni4ve outcomes of pa4ents undergoing MRgFUS thalamotomy. This study endorsed the safety profile of the procedure in terms of cogni4ve func4ons that cannot be evaluated in real-4me during the procedure unlike other aspects. The aim of the COGNIFUS Part 2 study was to inves4gate the cogni4ve trajectory of MRgFUS pa4ents over a one-year period, in order to confirm long-term safety and sa4sfac4on.Methods: We prospec4vely evaluated the cogni4ve and neurobehavioral profile of pa4ents with essen4al tremor (ET) or Parkinson's Disease (PD) related tremor undergoing MRgFUS thalamotomy at 1 year-follow-up following the treatment.Results: The sample consists of 50 pa4ents (male 76%; mean age ± SD 69.0 ± 8.56; mean disease dura4on ± SD 12.13 ± 12.59; ET 28, PD 22 pa4ents). A significant improvement was detected at the 1 year-follow-up assessment in anxiety and mood feelings (Hamilton Anxiety ra4ng scale 5.66±5.