Investigating cognitive impairment, biopsychosocial barriers, and predictors of return to daily life among older stroke survivors

Purpose The aim was to investigate the associations between cognitive impairment and biopsychosocial factors among older stroke survivors and predictors of poststroke return to daily life. Materials and methods This cross-sectional study involved 117 stroke survivors (61% men) with an average age of 77 years (range 65–91). The participants completed two questionnaires (Riksstroke and Short Form 36 questionnaires). The Montreal Cognitive Assessment (MoCA) was used to assess cognitive abilities. The International Classification of Functioning, Disability, and Health (ICF) framework guided the selection of biopsychosocial variables. We used Spearman’s correlation coefficient and multiple logistic regression in the analyses. Results The average MoCA score was 21.7 points (range: 4–30, SD 5.6). The need for assistance from relatives and professionals, need for help with dressing and household chores, reliance on others for mobility, and reading and balance problems were correlated with more severe cognitive impairment (r = 0.20–0.33). Cognitive impairment, fatigue, and balance issues predicted an unfavorable return to daily life (odds ratio: 6.2–6.8). Conclusion The study indicated that cognitive impairment is associated with difficulties in all ICF domains. Cognitive impairment, fatigue, and balance issues are associated with an unsuccessful return to daily life. Prioritizing these factors and screening for cognitive impairment with objective assessment tools may improve rehabilitation outcomes and enhance overall quality of life poststroke.


Introduction
Stroke is a leading cause of long-term disability worldwide, impacting the lives of more than 100 million individuals (1, 2).Stroke disrupts cerebral blood flow, causing tissue damage and neurological deficits.The neuroplasticity enables the brain to adapt and reorganize post-stroke, aiding recovery (3) but a common consequence of stroke is poststroke cognitive impairment (PSCI).PSCI is a broad term that includes conditions ranging from mild cognitive impairment to dementia.Common disorders are problems with memory, attention, executive abilities, language, visual processing, and information management (4,5).Usually, PSCI occurs within 3 months post-stroke, but can also develop over time (3).One year after stroke onset, one in four stroke survivors has PSCI (6, 7), and approximately seven of 10 stroke survivors will develop PSCI over time (8).PSCI often gives negative consequences on problem solving, organized planning and social interaction (9,10), which has a negative effect on individuals' overall health and well-being.There is a prioritized and ongoing global effort to understand the complexity of PSCI and develop interventions to prevent cognitive decline (11).PSCI predominantly affects the older population, which is growing globally (11,12), making it a priority in stroke research (11).An emerging issue in stroke research is investigating how cognitive function is connected to other biopsychosocial factors to develop personalized interventions (4).
Previous research has indicated that PSCI affects several biopsychosocial aspects.It affects the overall recovery process poststroke due to the negative impact on the body's motor function recovery (13).PSCI makes it more challenging to participate in physical rehabilitation; therefore, persons with PSCI are less physically active (14).Individuals with PSCI are also more prone to psychological deficits such as depression and fatigue (15, 16), which further affects their ability to engage in various leisure and social activities (17).PSCI affects both basic and instrumental activities of daily living, such as dressing, performing personal hygiene and household chores, and cooking (18).It also impairs communication (19), participation in social activities and interactions with others (18,20).Despite extensive PSCI research, the understanding of how different levels of PSCI affect biopsychosocial factors in older stroke survivors is incomplete.There is also limited research exploring which factors are associated with a successful return to daily life for older persons with PSCI.Previous studies investigating factors associated with return to daily life and leisure activities after stroke have shown that cognitive ability, age, and mobility are important factors (21,22).However, most related studies have focused on younger stroke survivors (23,24).
This study adopted a biopsychosocial perspective and used the International Classification of Functioning, Disability and Health (ICF) model (25) as a framework.This approach was chosen to capture the complexity of the interaction between PSCI and daily life.The study aimed to investigate (1) the associations between levels of cognitive impairment and biopsychosocial factors and (2) how these factors are associated with return to daily life.Through comprehensive insights into these biopsychosocial factors, poststroke well-being and recovery can be enhanced, allowing for tailored interventions for affected individuals.

Design
This was a cross-sectional study with data from a stroke population in a medium-sized Swedish municipality.This study was part of the Kumla Stroke Study and received ethical approval from the Swedish Ethical Review Authority (Reference No. 2019-02359).

Participants
In the Kumla Stroke Study, a total of 330 people diagnosed with stroke and living in the Kumla municipality were identified as of December 31, 2019 (26).The Swedish Stroke Register (Riksstroke), which is a nationwide quality registry for stroke care (27), medical journals and the local health care center diagnostic register (28), were used to identify the participants.From these 330 persons, we included a subsample who (1) had completed the Montreal Cognitive Assessment (MoCA) (29) and (2) were ≥ 65 years old (Figure 1).

Framework, measurement tools, and questionnaires
All the data were collected between October 2019 and June 2020.The Riksstroke (27) and Short-Form Health Survey (SF-36) (30) questionnaires were sent by mail and were completed by the participants themselves or with help from a family member.Participants could if they requested also receive support in completing the questionnaires by two physiotherapists, which also conducted the MoCA assessments, either at the local health care center or in the participant's home.All questionnaires and assessment tools, which were used in the study, were the Swedish versions.
The International Classification of Functioning, Disability and Health (ICF) (25) is a biopsychosocial model from the World Health Organization (WHO).The ICF describes a person's body functions, body structures, activity, participation, and contextual factors and is Flowchart of participants included in the study.1).
The Montreal Cognitive Assessment (MoCA) (29) is a screening instrument for cognitive impairment and has been validated for use in stroke survivors.The instrument evaluates attention, concentration, executive functions, memory, language ability, visuoconstructive ability, abstract thinking, numeracy, and orientation.The highest possible score is 30 points.Based on previous studies, the scores were categorized as follows: no cognitive impairment (24-30 points) (32), mild cognitive impairment (18-23 points), and severe cognitive impairment (1-17 points) (33).
The Riksstroke 1-year follow-up questionnaire is a Swedish questionnaire that has been validated for use in stroke survivors (27,34).It consists of 46 questions regarding stroke survivors' life situation, daily activities, and need for support and assistance.This study used 15 questions mainly concerning physical, psychological, and activity functions (Table 1).Two questions were converted to trichotomous variables (Do you feel tired?Do you feel depressed?Do you feel pain?) and two questions were converted to dichotomous variables (Do you need household assistance?Have you been able to return to the life and activities that you had before your stroke?).
The Short Form Health Survey 36 (SF-36) is a validated quality of life questionnaire consisting of 36 questions divided into eight domains (30).This study used the Social Function domain (SF) to describe a person's ability to socialize; the SF domain consists of two questions: (I) During the past 4

weeks, to what extent has your physical health or emotional problems interfered with your usual interactions? and (2)
During the last 4 weeks, how much of the time has your physical health or emotional problems interfered with your ability to socialize?(Table 1).

Statistical analysis
All analyses were conducted by using IBM SPSS statistics version 27 (IBM Corp., Armonk, NY, United States).Descriptive statistics describing the characteristics of the participants are presented as the mean, minimum, maximum, and standard deviation (SD).Spearman's rank correlation coefficient (Rho) was used to analyze correlations between the independent variables in Table 1 and the dependent variable (cognitive impairment).Cohen's levels of correlation were used (35).
Logistic regression was used to investigate predictors of return to daily life poststroke.The answer to the question "Have you been able to return to the life and activities that you had before your stroke?" was used as the dependent variable.Univariate logistic regression analysis was used to determine which independent variables should be included in the multiple regression analysis.A p value <0.05 was regarded as statistically significant.A test for multicollinearity with all the independent variables was conducted before the variables were included in the multiple regression analysis, and no substantial collinearity was found (tolerance >0.66 and variance inflation factor < 1.52).

Results
The study sample consisted of 117 persons (61% men), and the average age was 77 years, with a range from 65 to 91 years (SD 6.1).Over half of the participants resided with a spouse, and none were living in care homes; all participants were living in regular housing (Table 2).
The average MoCA score was 21.7 points, with a range from 4 to 30 points (SD 5.6).The results of the MoCA indicated that nearly half of the participants (48.7%) had no cognitive impairment, more than a fourth of the participants (28.2%) had moderate cognitive impairment, and less than a fourth of the participants had severe cognitive impairment (23.1%).In terms of self-reported memory problems, 20% of the individuals without cognitive impairment reported having memory problems.In contrast, among the participants with moderate cognitive impairment, fewer than one-third reported memory problems, and among those with severe cognitive impairment, less than half reported memory issues.More than 80% of the participants experienced fatigue, and more than half-experienced pain and depression.Forty percent of the participants also had problems with balance and socializing.The need for assistance with household chores was the most common assistance need, and most of the assistance was provided by close relatives (Table 2).

Associations between cognitive impairment and biopsychosocial factors
Severe cognitive impairment was significantly associated with more difficulties in eight out of 16 biopsychosocial factors: dressing assistance, assistance from close relatives, assistance from professionals, reliance on others for mobility, household chore assistance, reading, balance, and memory problems (Table 2).All eight variables had positive correlations (Rho = 0.02-0.33,weak-moderate); that is, more severe cognitive impairment was associated with more difficulties in these areas.However, the association between cognitive level and balance was not linear; participants who had moderate PSCI had more problems with balance than did those with no PSCI or severe PSCI.

Associations between biopsychosocial factors and return to daily life
The univariate regression results (Table 3) showed that the biopsychosocial factors household chore assistance, fatigue, balance, cognitive impairment, speech, dressing assistance, reading, and mobility were significantly associated with return to daily life and activities (p ≤ 0.001-0.04).
According to our multiple regression analysis (Table 3), cognitive impairment, balance, and fatigue were identified as significant predictors of nonreturn to daily life for stroke survivors.The odds of returning to daily life and activities were 6.2-6.8 times greater for persons who never or rarely felt tired, had no problems with balance and had no cognitive impairment than for those who had problems in these areas.Less than 20% of the participants who had problems with balance, often or always felt tired or had severe cognitive impairment returned to daily life and activities after stroke.

Discussion
The overall findings of this study indicate significant associations between cognitive impairment and various biopsychosocial factors across all ICF domains.While the weak to moderate correlations indicate that the relationships between these factors are not notably strong, this study's findings still emphasize the importance of recognizing cognitive impairment in stroke care but also the need for early detection, considering its impact on stroke survivors' return to daily life.
One of the aims of this study was to investigate how cognitive impairment was associated with biopsychosocial factors; severe cognitive impairment was most strongly associated with factors within the "Activity and participation" and "Contextual factors" ICF domains.The findings revealed that an increased need for assistance in tasks involving dressing, mobility, and household chores was associated with more severe cognitive impairment.This finding is in line with that of another study highlighting the association between an increased need for support in basic and instrumental activities of daily living and more severe cognitive impairment (36).Severe cognitive impairment was also associated with an increased demand for assistance from both family members and professionals.Earlier findings indicated that people with cognitive impairment required 2-5 times more support than did those without cognitive impairment (37).Our findings imply that cognitive impairment impacts a wide range of daily activities.By combining the ICF model with the MoCA, as demonstrated in this study, we were able to pinpoint the specific biopsychosocial factors most impacted by the severity of cognitive impairment.Understanding individual needs can facilitate the customization of stroke rehabilitation programs and enhance stroke survivors' daily lives, as well as ease the burden on families and society.
The second aim of this study was to explore the associations between biopsychosocial factors and return to daily life.Return to daily life falls under the ICF-domain of "Activity and participation." Return to daily life was associated with three factors: cognitive impairment, balance, and fatigue.These factors were all included in the ICF domain of "Body functions." The first factor associated with an unsuccessful return to daily life was cognitive impairment, which often affects stroke survivors' executive functions and has a negative impact on problem solving, planning, and social interaction, which are all essential factors for returning to daily life (9,10).However, a similar study exploring predictors of return to daily activities poststroke found no associations with cognitive impairment (21).However, that study relied on participants' self-assessments of their cognitive abilities, which may have influenced the results.In our study, using the MoCA, we revealed a significant difference between participants' self-perceived memory problems and their actual MoCA results.Less than one-third of the participants with moderate cognitive impairment and less than half of the participants with severe cognitive impairment recognized their memory issues.If individuals fail to acknowledge cognitive problems, it becomes crucial for health care providers to step in.Previous research frequently highlights the tendency to overlook cognitive impairment poststroke in favor of physical concerns (4,38).For instance, a study showed that 70% of stroke survivors discharged with clinical successful  recovery according to modified Rankin Scale, and no apparent functional disability, yet demonstrated various cognitive deficits 3 months post-stroke (39).Studies also indicate that health care professionals struggle to detect and prioritize cognitive impairment within brief care periods (4,5).In essence, recognizing the gap between self-perceptions and objective assessments underscores the urgent need for comprehensive cognitive evaluation in clinical stroke care practice but also the need to do cognitive assessment follow-ups.Balance challenges were also significantly associated with an unsuccessful return to daily life.Another study revealed that the primary hindrance to resuming physical activity and daily activities was fear of falling due to balance issues (39).Moreover, avoiding situations perceived as posing a fall risk has emerged as the primary cause of the decrease in physical mobility, limited social participation, and reduced quality of life among stroke survivors (40,41).This underscores the importance of considering balance challenges in a broader context and recognizing the wider psychosocial impact.Using a biopsychosocial approach and combining interventions that provide support regarding both balance and psychological issues may therefore enhance overall recovery for stroke survivors and improve their ability to return to daily life.
In this study, experiencing fatigue emerged as the final factor associated with an unsuccessful return to daily life.A total of 85% of the participants experienced fatigue poststroke, which aligns with previous findings (42).Poststroke fatigue notably affects quality of life and limits individuals' participation in various daily activities (43).Research has also indicated that stroke survivors with both reduced physical abilities

TABLE 1
Description of ICF domains, categories and codes of the Riksstroke and SF-36 questionnaires.

TABLE 2
Results from Riksstroke and SF-36 questionnaires divided into groups based on MoCA scores.

TABLE 3
Univariate and multiple logistic regression analysis.Dependent variable: Have you been able to return to the life and activities that you had before your stroke?