AUTHOR=Safiri Saeid , Ghaffari Jolfayi Amir , Mousavi Seyed Ehsan , Nejadghaderi Seyed Aria , Sullman Mark J. M. , Kolahi Ali-Asghar 

TITLE=Global burden of multiple sclerosis and its attributable risk factors, 1990–2019

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1448377

DOI=10.3389/fneur.2024.1448377

ISSN=1664-2295

ABSTRACT=Background: Multiple sclerosis (MS) is a progressively and debilitating disease disorder that has shown seen a notable rise inan increasing prevalence in recent years. We aimed to reportThis study examines the burden of MS from 1990 to 2019, providing a detailed analysis by age, gendersex, age, sex and sociodemographic index (SDI) in across 204 countries and territories.Methods: Publicly accessible dData on the prevalence, death and disability-adjusted life years (DALYs) due attributable to MS were accessed obtained from the publically available Global Burden of Disease 2019 project. The estimates were are reportedreported as numbers, percentages, and age-standardised rates per 100,000, along accompanied bywith 95% uncertainty intervals.In 2019, MS accounted accounted for 1.8 million prevalent cases, 22.4 thousand deaths and 1.2 million DALYs worldwide. There were Ssignificant decreases declines were observed in the global age-standardised prevalence, death mortality and DALY rates of MS over the period 1990-2019 from 1990 to 2019. In 2019, females exhibited a higher the global point prevalence and a greater total number of prevalent MS cases were than higher in females than males across all age groups. At the regional level, we observed a non-linear association relationship was observed between the age-standardised DALY rate of MS and the SDI.Although the global age-standardized DALY rate of MS decreased between 1990 and 2019, MS continues to account for a considerable portion number of DALYs and prevalent cases and DALYs. Integrating MS and its associated risk factors into healthcare planning is vital, particularly especially in regions areas with high levels of socioeconomic development.