AUTHOR=van Boxel Stan C. J. , Vermorken Bernd L. , Volpe Benjamin , Guinand Nils , Perez-Fornos Angélica , Devocht Elke M. J. , van de Berg Raymond 

TITLE=The vestibular implant: effects of stimulation parameters on the electrically-evoked vestibulo-ocular reflex

JOURNAL=Frontiers in Neurology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1483067

DOI=10.3389/fneur.2024.1483067

ISSN=1664-2295

ABSTRACT=The vestibular implant is a neural prosthesis which offers a potential treatment approach for patients suffering from vestibulopathy. Investigating the influence of electrical stimulation parameters is essential to improve the vestibular implant response. Optimization of the response focuses on the electrically evoked vestibulo-ocular reflex. It aims to facilitate high peak-eye-velocities and adequate alignment of the eye movement responses. In this study, the basic stimulation parameters of the vestibular implant were tested for their effect on the electrically evoked vestibuloocular reflex.Methods: Four stimulation parameters, including the stimulation amplitude, phase duration, stimulus rate and speed of change of stimulation, were systematically tested in a cohort of nine subjects with a vestibulo-cochlear implant. These parameters were tested to evaluate their effect on fitting settings (i.e. threshold of activation, upper comfortable limit and dynamic range) as well as on the electrically evoked vestibulo-ocular reflex (peak-eye-velocity and alignment).Results: It was confirmed that, in addition to current amplitude, the peak-eye-velocity of the response can be increased by increasing the phase duration and pulse rate. Both parameters have little effect on the alignment of the eye response. However, a longer phase duration decreased the range between the threshold of activation and the upper comfortable limit of the electrical stimulation (i.e. dynamic range). Furthermore, these results show that next to the amplitude of the stimulation, the speed of change in stimulation has a determinative positive effect on the peak-eye-velocity.The observations in this study imply that the vestibular implant response, in terms of peakeye-velocity, can be optimized with a higher pulse rate and longer phase duration. However, this comes at a trade-off between the dynamic range and power consumption. This study provides essential insights for fitting strategies in future vestibular implant care.