AUTHOR=Lou Chen , Xu Dongjuan 

TITLE=A nomogram for predicting early thrombolytic efficacy in stroke patients

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1452856

DOI=10.3389/fneur.2025.1452856

ISSN=1664-2295

ABSTRACT=BackgroundThe purpose of this study was to develop and verify a novel nomogram for predicting stroke patients’ early thrombolytic efficacy.MethodsWe collect basic facts and clinical data of stroke patients with intravenous thrombolysis. A nomogram was established for predicting early thrombolytic efficacy in these people. The LASSO regression method and multivariate logistic regression were used to filter variables and choose predictors. Predictors were applied to develop a model. The model’s discriminatory capacity was assessed by computing the area under the curve. In addition, the model’s calibration analysis and decision curve analysis were performed.ResultsUsing multivariate logistic regression and LASSO regression techniques, five variables were chosen. These variables were age, NIHSS score before thrombolysis, prothrombin time, neutrophil count, and monocyte count. The AUC of the prediction model was 0.761 (95% CI, 0.717–0.805) in the training set and 0.744 (95% CI, 0.653–0.835) in the test set. The decision curve showed that the threshold probabilities for the effectiveness of early thrombolysis in cerebral infarction are 25–67% and 25–73% in the training set and test set, respectively.ConclusionA novel nomogram with age, NIHSS score before thrombolysis, prothrombin time, neutrophil count, and monocyte count as variables has the potential to predict early thrombolytic efficacy in stroke patients. Physicians could utilize this handy nomogram to make better decisions for stroke patients with intravenous thrombolysis.