AUTHOR=Bauer Christopher E. , Zachariou Valentinos , Pappas Colleen , Maillard Pauline , DeCarli Charles , Caprihan Arvind , Gold Brian T. 

TITLE=Healthy dietary intake diminishes the effect of cerebral small vessel disease on cognitive performance in older adults

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1508148

DOI=10.3389/fneur.2025.1508148

ISSN=1664-2295

ABSTRACT=IntroductionWe evaluated whether regular dietary intake of nutrients commonly found in fish, unsaturated oils, and nuts would moderate the associations between neuroimaging biomarkers of cerebral small vessel disease (cSVD) and cognitive function in older adults.MethodsDietary information, Montreal Cognitive Assessment (MoCA) scores, and magnetic resonance imaging (MRI) scans were collected from 71 older adults without dementia (60–86 years). MRI biomarkers of cSVD were calculated for each participant. Multivariate linear regression models were computed using dietary intake as the moderating variable. Covariates included age, sex, and estimated intracranial volume.ResultsDietary intake moderated the association between several cSVD biomarkers and MoCA scores such that the expected negative association between cSVD biomarkers and cognition was seen at low levels of healthy dietary intake, but not at medium or high levels. A dietary intake by age moderation was not observed.DiscussionOur findings indicate that healthy dietary intake may confer cognitive reserve against cSVD in older adults.