AUTHOR=Vodă Ileana Maria , Tiu Vlad Eugen , Răuță Luiza , Ciucur Paul , Mușuroi Andreea Ioana , Tomescu Alina Flavia , Humă Nicoleta Laura , Dobrițoiu Florin , Terecoasă Elena , Negreanu Lucian , Tiu Cristina 

TITLE=Ocrelizumab-induced colitis—critical review and case series from a Romanian cohort of MS patients

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1530438

DOI=10.3389/fneur.2025.1530438

ISSN=1664-2295

ABSTRACT=BackgroundWidespread use of ocrelizumab, an anti-CD20 monoclonal antibody, for treating patients with multiple sclerosis (MS), has led to an increase in reported adverse events following real-world observation. Among these, drug-induced colitis is a rare, but severe side effect, prompting a recent FDA statement regarding this safety concern. Objectives: We analyzed a cohort of ocrelizumab treated patients in our MS center to evaluate the incidence of drug-induced colitis.MethodsWe present a critical review of the available literature on diagnosis and management of anti-CD20 induced colitis and display a case series of 3 suspected patients in our cohort.ResultsTwo patients met the full criteria for ocrelizumab-induced colitis, while a third partially met the criteria. Following symptomatic treatment and discontinuation of ocrelizumab, the patients showed favorable outcomes.ConclusionOcrelizumab-induced colitis is a rare, but severe adverse event. Its incidence may be higher than expected, reaching 1,95% in our cohort of MS patients. Further reporting of such cases is essential to broaden our understanding of this side effect.