AUTHOR=He Wenchao , Chen Shuangshuang , Chen Ruyang , Zhang Jun , Zhang Xuehua , Wu Minzhi , Zhang Dan , Zhu Fengfeng , He Fanghua , Xv Yating , Lei Na , Zheng Wenhui , Shan Xinyi , Dai Jun 

TITLE=Integrated multi-biomarker panel of CXCL13, HS-CRP, and WBC counts predicts outcomes in stroke neurosyphilis patients treated with HBO and TUS-NMES

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1530447

DOI=10.3389/fneur.2025.1530447

ISSN=1664-2295

ABSTRACT=BackgroundNeurosyphilis results from Treponema pallidum invading the central nervous system, leading to severe neurological issues like stroke. Combining hyperbaric oxygen (HBO) therapy and transcranial ultrasound neuromuscular stimulation (TUS-NMES) shows promise in improving outcomes.ObjectiveThis study evaluates the predictive value and clinical significance of CXCL13, WBC, and Hs-CRP levels in neurosyphilis patients undergoing HBO and TUS-NMES therapy.MethodsThe study included 158 neurosyphilis stroke patients treated from June 2022 to January 2024. Assessments of limb motor, cognitive functions, daily living abilities, and cerebrospinal fluid biomarkers were conducted pre- and post-four weeks of combined therapy.ResultsAfter treatment, there was a significant improvement in FMA, MoCA, and MBI scores (p < 0.001). CXCL13 levels significantly decreased post-treatment, correlating with improved patient outcomes. The study found strong predictive values for CXCL13 levels in determining the efficacy of rehabilitation, with the combination of CXCL13, WBC, and Hs-CRP showing the highest predictive accuracy.ConclusionHBO and TUS-NMES significantly enhance recovery in neurosyphilis stroke patients. CXCL13, WBC, and Hs-CRP effectively predict rehabilitation outcomes, highlighting their value in clinical management.