AUTHOR=Yang Qian , Chang Yingying , Zhao Yinuo , Lai Yanhui , Liu Xuzhao , Xiao Ying , Li Na , Cui Shuhua , Wang Zhibo , Cui Ling , Zhao Yubin 

TITLE=Risk factors for 1-year peripheral neuropathy and F-wave abnormalities after COVID-19: a prospective cohort study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1532046

DOI=10.3389/fneur.2025.1532046

ISSN=1664-2295

ABSTRACT=ObjectiveTo explore the risk factors for peripheral neuropathy (PNP) and F-wave abnormality during one-year rehabilitation for coronavirus disease 2019 (COVID-19).MethodsThis prospective cohort study included patients with COVID-19 who were discharged from Shijiazhuang People’s Hospital after treatment and routine rehabilitation between December 2020 and April 2021. Multivariable logistic regression analysis was used to analyze the independent risk factors for PNP and F-wave abnormality. p-values <0.0125 were considered significant in the multivariable analyses to account for type I error.ResultsA total of 313 patients with COVID-19 [aged 49.0 (IQR 33.0–58.0) years, and 191 (61.0%) females] were included. During one-year follow-up, 232 (74%) patients developed PNP (PNP group), and 81 (26%) did not (non-PNP group). In the PNP group, 51 (16%) patients had mononeuropathy, and 181 (58%) had polyneuropathy. Additionally, F-wave abnormality was detected in 22 (7%) out of 313 patients. Multivariable logistic regression analysis showed that age [odds ratio (OR) = 1.22, confidence interval (CI): 1.05–1.41, p = 0.009] was independently associated with PNP. College or higher education (OR = 5.07, 95% CI: 1.80–13.90, p = 0.002) was independently associated with mononeuropathy.ConclusionAge might be an independent risk factor for PNP, while higher education was associated with mononeuropathy.