AUTHOR=Yangi Kivanc , Hong Jinpyo , Gholami Arianna S. , On Thomas J. , Reed Alexander G. , Puppalla Pravarakhya , Chen Jiuxu , Calderon Valero Carlos E. , Xu Yuan , Li Baoxin , Santello Marco , Lawton Michael T. , Preul Mark C. 

TITLE=Deep learning in neurosurgery: a systematic literature review with a structured analysis of applications across subspecialties

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1532398

DOI=10.3389/fneur.2025.1532398

ISSN=1664-2295

ABSTRACT=ObjectiveThis study systematically reviewed deep learning (DL) applications in neurosurgical practice to provide a comprehensive understanding of DL in neurosurgery. The review process included a systematic overview of recent developments in DL technologies, an examination of the existing literature on their applications in neurosurgery, and insights into the future of neurosurgery. The study also summarized the most widely used DL algorithms, their specific applications in neurosurgical practice, their limitations, and future directions.Materials and methodsAn advanced search using medical subject heading terms was conducted in Medline (via PubMed), Scopus, and Embase databases restricted to articles published in English. Two independent neurosurgically experienced reviewers screened selected articles.ResultsA total of 456 articles were initially retrieved. After screening, 162 were found eligible and included in the study. Reference lists of all 162 articles were checked, and 19 additional articles were found eligible and included in the study. The 181 included articles were divided into 6 categories according to the subspecialties: general neurosurgery (n = 64), neuro-oncology (n = 49), functional neurosurgery (n = 32), vascular neurosurgery (n = 17), neurotrauma (n = 9), and spine and peripheral nerve (n = 10). The leading procedures in which DL algorithms were most commonly used were deep brain stimulation and subthalamic and thalamic nuclei localization (n = 24) in the functional neurosurgery group; segmentation, identification, classification, and diagnosis of brain tumors (n = 29) in the neuro-oncology group; and neuronavigation and image-guided neurosurgery (n = 13) in the general neurosurgery group. Apart from various video and image datasets, computed tomography, magnetic resonance imaging, and ultrasonography were the most frequently used datasets to train DL algorithms in all groups overall (n = 79). Although there were few studies involving DL applications in neurosurgery in 2016, research interest began to increase in 2019 and has continued to grow in the 2020s.ConclusionDL algorithms can enhance neurosurgical practice by improving surgical workflows, real-time monitoring, diagnostic accuracy, outcome prediction, volumetric assessment, and neurosurgical education. However, their integration into neurosurgical practice involves challenges and limitations. Future studies should focus on refining DL models with a wide variety of datasets, developing effective implementation techniques, and assessing their affect on time and cost efficiency.