AUTHOR=Zhao Huiyu , Zhang Miaoyi , Tang Weijun , Jin Luyuan , Tang Jie , Shi Langfeng , Deng Xiao , Fu Jianhui , Zou Weiwen 

TITLE=Deep learning-based automated segmentation for the quantitative diagnosis of cerebral small vessel disease via multisequence MRI

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1540923

DOI=10.3389/fneur.2025.1540923

ISSN=1664-2295

ABSTRACT=ObjectiveExisting visual scoring systems for cerebral small vessel disease (CSVD) cannot assess the global lesion load accurately and quantitatively. We aimed to develop an automated segmentation method based on deep learning (DL) to quantify the typical neuroimaging markers of CSVD on multisequence magnetic resonance imaging (MRI).Materials and methodsMRI scans from internal (July 2018 to July 2022) and external (November 2012 to January 2015) datasets were analyzed. A DL-based segmentation method was developed to evaluate the quantitative volumes of white matter hyperintensity (WMH), cerebral microbleeds (CMBs), lacunes, and enlarged perivascular spaces (EPVSs) according to the segmentation results. Dice and other quantitative metrics were used to access the DL segmentation results. Pearson correlation coefficients were used for correlation analysis, and the differences in marker volumes among different visual scores were assessed via analysis of variance (ANOVA). Finally, a quantitative Z score was calculated to represent CSVD-related brain burden.ResultsA total of 105 internal patients (64.8 ± 7.4 years, 70 males) and 58 external patients (68.2 ± 6.8 years, 29 males) were evaluated. The Dice values for WMH, CMBs, lacunes, and EPVSs in the internal dataset were 0.85, 0.74, 0.76, and 0.75, respectively. The positive correlation between the DL and the manual approach results was excellent (overall Pearson correlation = 0.968, 0.978, 0.948, and 0.947, respectively). The predicted volumes of the CSVD neuroimaging markers showed significant differences among the groups with different visual scores (p < 0.001). The quantitative Z scores reflecting CSVD global burden also correlated well with the widely recognized total burden score (p < 0.001).ConclusionAn automated DL model was developed for the segmentation of four CSVD neuroimaging markers on multisequence MRI, providing a strong basis for further CSVD research.