AUTHOR=Shang Meiling , Shang Ailing , Xu Yu 

TITLE=Association between admission Braden Skin Score and delirium in surgical intensive care patients: an analysis of the MIMIC-IV database

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1555166

DOI=10.3389/fneur.2025.1555166

ISSN=1664-2295

ABSTRACT=BackgroundThe Braden Skin Score (BSS), a tool for assessing pressure ulcers, is increasingly recognized for its prognostic value in various disorders. However, its link to critical delirium in surgical patients remains understudied. This study aimed to explore the association between BSS upon admission and the risk of delirium in SICU patients.MethodsThis retrospective observational cohort study used data from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The primary outcome was incidence of delirium. Feature importance of BSS was initially assessed using a machine learning algorithm, while restricted cubic spline (RCS) models and multivariable logistic analysis evaluated the relationship between BSS and delirium. Additionally, Kaplan–Meier analysis and mediation analysis were conducted to explore interactions among BSS, delirium, and short-term mortality.ResultsA total of 4,899 patients were included in the study, among whom 1,491 were diagnosed with delirium. The Boruta algorithm identified BSS as a significant predictor of delirium occurrence. RCS models demonstrated a non-linear positive relationship between BSS and delirium. Based on RCS curves, the optimal threshold for BSS was established at 16, thereby categorizing participants into two groups: those with BSS < 16 and those with BSS ≥ 16. Multivariable logistic regression analysis revealed that lower BSS was positively correlated with an increased risk of delirium. These findings exhibited robust consistency across subgroup analyses and sensitivity analyses. Furthermore, patients in lower BSS groups had a higher 90-day mortality, with delirium mediating an indirect effect on this outcome.ConclusionThe low BSS was independently associated with an increased risk of delirium in critically ill surgical patients. Patients exhibiting a BSS below 16 demonstrated heightened susceptibility to the onset of delirium, thereby necessitating vigilant monitoring and timely intervention. Larger prospective studies are needed to confirm these findings.