AUTHOR=Dong Chao , Tang Zhaobing , Bai Xingang , Que Fangxu , Bai Ling , Huang Yi , He Sheng , Pang Rizhao 

TITLE=Study on the link between neutrophil percentage to albumin ratio and acute kidney injury in severe ischemic stroke patients during hospitalization

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1580248

DOI=10.3389/fneur.2025.1580248

ISSN=1664-2295

ABSTRACT=BackgroundThis study aimed to investigate the association between the neutrophil percentage-to-albumin ratio (NPAR) and the occurrence of acute kidney injury (AKI) in patients with severe ischemic stroke.MethodsBased on the EICU Clinical Research Database (EICU-CRD), 1,027 patients with severe ischemic stroke were enrolled (AKI group: 137 cases, non-AKI group: 890 cases). Data description: Non-normally distributed variables were expressed as median (IQR), and categorical variables were presented as frequency (weighted percentage). Statistical analysis: Intergroup comparisons were performed using the Wilcoxon rank-sum test and Rao-Scott chi-square test. Multivariate logistic regression and trend analysis were employed to evaluate the predictive value of NPAR for AKI, with adjustments for confounding factors.Results1. NPAR levels: The AKI group exhibited significantly higher NPAR than the control group (29 ± 10 vs. 24 ± 7, p < 0.001). 2. Risk prediction: After adjusting for confounding factors including liver function, electrolyte levels, blood cell count, history of renal insufficiency, furosemide use, and vital signs, NPAR remained an independent risk factor for AKI (OR = 1.041, 95% CI: 1.007–1.076, p-value = 0.0162). 3. Dose-effect relationship: A significant increase in AKI risk was observed with each one-quarter increase in NPAR (Q4 vs Q1, OR: 3.598, 95% CI: 1.482–9.12, p-value: 0.0056, p for trend: 0.0028). 4. Subgroup analysis: The impact of elevated NPAR on AKI risk was more pronounced in male patients.ConclusionElevated NPAR levels significantly increase the risk of acute kidney injury in patients with severe ischemic stroke, demonstrating a clear dose–response relationship. These findings suggest that NPAR may serve as a potential biomarker.