AUTHOR=Xu Fei , Liu Hongwei , Li Meng , Zhang Minheng , Chen Xuan , Hou Miaomiao 

TITLE=Hypertension mediates the association between weight-adjusted waist index and new onset stroke risk in middle-aged and older Chinese adults: evidence from the CHARLS study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1587176

DOI=10.3389/fneur.2025.1587176

ISSN=1664-2295

ABSTRACT=BackgroundThe weight-adjusted waist index (WWI) serves as a novel body metric for evaluating abdominal adiposity. However, the association between WWI and stroke risk across varying blood pressure statuses remains poorly understood.MethodsThis study included 12,580 individuals aged 45 and above with no prior stroke incidents, drawn from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2020. Multiple analytical approaches were utilized to assess the relationship linking WWI and incident stroke, including Cox proportional hazards regression, restricted cubic splines, subgroup analyses, and sensitivity analyses. The predictive capacity of WWI for stroke was evaluated through receiver operating characteristic (ROC) curves, with further stratification based on blood pressure status and other anthropometric indicators. A mediation approach was employed to investigate the intermediary role of hypertension in the WWI-stroke association.ResultsThe investigation recruited 12,580 participants, 727 (5.78%) experienced stroke events. Across all Cox regression models, increased WWI consistently demonstrated a significant association with elevated stroke risk (HR = 1.12, 95%CI: 1.02–1.22, p = 0.012), particularly in individuals with pre-hypertension (HR = 1.20, 95% CI: 1.00–1.46, p = 0.044) and hypertension (HR = 1.13, 95% CI: 1.01–1.25, p = 0.032). Additional sensitivity examinations further corroborated the consistency of our results regarding WWI’s predictive accuracy for stroke risk. The ROC curves revealed that WWI exhibited the highest predictive accuracy for stroke risk (AUC = 0.679) among the anthropometric indices evaluated, outperforming other conventional indicators. The predictive performance was significantly stronger in the hypertension group (AUC = 0.672) than in different subgroups. Mediation effect analysis indicated that hypertension partially mediated the impact of WWI on stroke (β: 0.015, p < 0.001), accounting for 12% of WWI’s total effect on stroke incidence.ConclusionThis study revealed that elevated WWI levels independently contribute to a higher stroke occurrence rate in middle-aged and older adult demographics, with a particularly pronounced effect observed in hypertensive individuals.