AUTHOR=Gu Lei , Sun Zhezhe , Hou Xiangqing , Zhang Wanli , Deng Binbin , Chen Xiaoyang , Li Xiang , Cheng Yifan 

TITLE=Hidden risk patterns among acute ischemic stroke patients identified by latent class analysis

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1597361

DOI=10.3389/fneur.2025.1597361

ISSN=1664-2295

ABSTRACT=BackgroundFew studies focus on the comprehensive influence of multiple risk factors on the follow-up outcomes of acute ischemic stroke (AIS) patients. To fill this gap, this study aims to identify different subgroups with specific clinical characteristics and risk patterns among patients with AIS and to provide individualized treatment plans accordingly.MethodsWe obtained clinical follow-up data from 448 AIS patients within 72 h of admission. Subgroup patients were characterized by latent class analysis (LCA) using 5 risk factors of AIS. Cox proportional hazard regression analysis was used to explore the relationship between classified risk factor patterns and functional outcomes of patients with AIS at 3 months.FindingsWe obtained two risk factor patterns as “Elderly with low lymphocytes,” and “Participants with low neutrophils and high lymphocytes.” Class 1 (n = 214, 47.8%) had lower lymphocytes levels and was mainly elderly. Patients in Class 2 (N = 234, 53.2%) had higher lymphocytes levels and lower neutrophils levels than those in Class 1. In addition, CRP levels were mostly low in both Classes 1 and 2. There was a significant difference in poor functional outcomes between the two patterns after adjusting various confounders (p < 0.001). Compared with patients in Class 2, patients in Class 1 had a higher risk of adverse functional outcomes (adjusted Hazard Ratio, 3.21; 95% confidence interval: 2.07–4.98; p < 0.001).InterpretationIn our study, LCA was used to identify a 2-Class LCA model that was shown distinct clinical features and laboratory measurements among AIS patients. Our findings are beneficial for health management and therapy.