AUTHOR=Song Xuhua , Liang Jingwei , Tian Congzhe 

TITLE=Increased 25-hydroxycholesterol as an indicator for patients with vestibular neuritis

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1600185

DOI=10.3389/fneur.2025.1600185

ISSN=1664-2295

ABSTRACT=BackgroundVestibular neuritis (VN) is one of the most common diseases in vestibular vertigo. 25-hydroxycholesterol (25-HC) was correlated to neuroinflammation, however, whether the level of serum 25-HC could be used to diagnose the VN occurrence remains unclear.MethodsThe enrolled patients were divided into VN and healthy control groups. Afterwards, the potential risk factors were assessed in these two groups. Subsequently, the complete blood count was performed upon hospital admission.ResultsThe serum 25-HC and C-reactive protein (CRP) were detected in two groups using liquid chromatography-mass spectrometry and a high-sensitive immunonephelometric assay. Moreover, the correlation of 25-HC to inflammatory factors was analyzed. Finally, the receiver operating characteristic curve analysis was performed to predict the diagnosis effect of 25-HC in VN occurrence. The age, gender, BMI, living habits, disease history, and cholesterol did not affect the VN occurrence. However, 25-HC was dramatically increased in VN patients, meanwhile, peripheral blood leukocyte and neutrophil/lymphocyte ratio were also elevated in VN patients. Importantly, 25-HC was positively correlated to CRP and leukocytes. Additionally, the level of serum 25-HC could be used to predict the VN occurrence.ConclusionSerum 25-HC may diagnose the occurrence of VN.