AUTHOR=Liao Yuanchen , Luo Lei , Ma Qiang , Gao Xiaofeng , Chen Yao , Yan Siyang , He Menghao , Liu Lijuan , Zhou Desheng 

TITLE=Research progress on the correlation between biological rhythms and the blood-brain barrier after ischemic stroke

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1627172

DOI=10.3389/fneur.2025.1627172

ISSN=1664-2295

ABSTRACT=Biological rhythms play a critical role in regulating human physiology and have been implicated in the onset, progression, and recovery of ischemic stroke (IS). This review summarizes recent experimental and clinical studies that associate circadian regulation with post-stroke blood–brain barrier (BBB) repair, focusing on the role of molecular clock components. Core clock components, including BMAL1 and CLOCK, influence BBB integrity by regulating tight junction protein expression, angiogenesis, neuroimmune responses, and neuroendocrine signaling. Finally, we discuss emerging chronotherapeutic strategies that integrate circadian biology into stroke rehabilitation.