AUTHOR=Huang Yung-Sheng , Chang Hen-Hong , Chiang John Y. , Hsu Po-Chi , Lo Lun-Chien 

TITLE=Retroflex tongue as a non-invasive neurological marker of functional severity in older adults with ischemic stroke: a retrospective observational study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1632351

DOI=10.3389/fneur.2025.1632351

ISSN=1664-2295

ABSTRACT=BackgroundWith the growing global burden of ischemic stroke in aging populations, there is increasing interest in simple and non-invasive neurological markers to support early risk stratification and functional prognosis. Retroflex tongue (RT) and tongue deviation (TD) are observable signs of cranial nerve dysfunction; however, their comparative predictive value for stroke severity remains unclear.MethodsIn this retrospective observational study, 308 older adults (mean age: 69.1 years) hospitalized with ischemic stroke were enrolled. Tongue motor function was evaluated using an automatic tongue diagnosis system (ATDS). Deviation angles were measured, and the presence or absence of RT was assessed by trained traditional Chinese medicine physicians. Stroke severity and functional outcomes were evaluated using the National Institutes of Health Stroke Scale (NIHSS), Barthel Index, and length of hospital stay.ResultsAmong the 308 patients, 59 (19.2%) exhibited TD and 249 (80.8%) did not. No significant differences were found in baseline characteristics between TD groups, except for deviation angle (TD: 9.72° ± 8.91° vs. non-TD: 6.40° ± 7.84°, p = 0.011). Patients without RT had significantly worse clinical outcomes, including longer hospital stays (32.0 vs. 25.9 days, p = 0.007), higher NIHSS scores (14.1 vs. 8.9, p < 0.001), and lower Barthel Index scores (18.6 vs. 35.0, p < 0.001), compared to those with RT. In contrast, TD showed no significant association with these outcomes. Multivariate regression identified non-RT as an independent predictor of stroke severity. ROC analysis supported the discriminative value of RT (AUC = 0.703 for NIHSS ≥ 9; AUC = 0.712 for Barthel ≤ 17), whereas TD showed poor predictive ability (AUC = 0.524 and 0.570, respectively).ConclusionAbsence of retroflex tongue is more strongly associated with stroke severity and functional impairment than tongue deviation. As a simple, observable motor sign, RT may serve as a practical bedside indicator for early neurological assessment. However, given its preliminary status, further validation in prospective, multi-center studies is warranted before clinical application.