AUTHOR=Yacoubian Talene A. , Qin Hongwei , Amara Amy , Stover Natividad , Ruffrage Lauren , Zhang Yue , Kennedy Richard , Geldmacher David , Gerstenecker Adam , Standaert David G. , Benveniste Etty N. 

TITLE=Inflammatory changes in early dementia with Lewy bodies

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1640614

DOI=10.3389/fneur.2025.1640614

ISSN=1664-2295

ABSTRACT=ObjectiveTo examine if immune cell changes are present in early stages of Dementia with Lewy Bodies (DLB).BackgroundEvidence for inflammation in synucleinopathies has been building. An extensive number of studies have documented inflammatory changes in Parkinson’s disease (PD), but much less is known about DLB. Post-mortem DLB brains show T-cell infiltration, and flow cytometry and cytokine/chemokine measures in DLB subjects have suggested the presence of inflammatory responses in DLB. However, there is limited understanding if immune cell changes are present at the earliest stages of DLB.MethodsWe recruited a small, exploratory cohort of nine subjects with Mild Cognitive Impairment—Lewy Bodies (MCI-LB) as part of the broader Alabama Udall cohort study, which is focused on the role of inflammation in early PD. The MCI-LB cohort was compared to subjects with de novo PD (n = 64) and healthy controls (n = 70) from the larger Alabama Udall cohort. Subjects underwent clinical assessments, including Movement Disorder Society-United Parkinson’s Disease rating scale (MDS-UPDRS), and comprehensive cognitive assessment. Blood was obtained for flow cytometry and cytokine/chemokine analyses.ResultsDemographics and medical history were comparable between groups. Significant differences in University of Pennsylvania Smell Identification Test, Schwab and England Activities of Daily Living, and MDS-UPDRS scores were observed between the groups. MCI-LB subjects had poorer cognitive composite scores compared to PD participants. MCI-LB subjects demonstrated a robust 60% reduction in mature neutrophils compared to healthy controls.ConclusionOur data show changes in innate immune cells in MCI-LB compared to healthy controls in this small exploratory study. A larger cohort study is needed to validate these findings.