AUTHOR=Cha Zaihong , Li Yu , Pu Jianeng , Zhang Yuansheng , Lu Qixiong , Huang Wei , Li Tao , Lu Xiaoyang 

TITLE=Exosome-mediated repair of spinal cord injury: cellular sources, mechanisms of action, and combined therapeutic strategies

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1645457

DOI=10.3389/fneur.2025.1645457

ISSN=1664-2295

ABSTRACT=Spinal cord injury (SCI) presents a significant clinical challenge due to its complex pathology and limited capacity for self-repair, often resulting in substantial physical dysfunction. Conventional treatments emphasize symptom management, yet usually fail to achieve nerve regeneration and full functional recovery. Recently, Exosomes(Exos) have gained attention as key modulators in biological processes such as immune regulation, intercellular communication, and tissue repair, showing promise in nerve injury and regeneration. This review synthesizes recent research on Exosome-based SCI therapies, including their biological origins, mechanisms, potential applications, and current limitations. Although Exos' research in SCI is nascent, early studies indicate promising safety and efficacy. Future studies are encouraged to delve deeper into Exos preparation, optimization, and delivery to maximize therapeutic effectiveness, potentially advancing SCI treatment options.