AUTHOR=Akinwumi Patrick O. , Ojo Stephen , Nathaniel Thomas I. , Wanliss James , Karunwi Olukayode , Sulaiman Mercy 

TITLE=Evaluating machine learning models for stroke prediction based on clinical variables

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1668420

DOI=10.3389/fneur.2025.1668420

ISSN=1664-2295

ABSTRACT=IntroductionStroke remains one of the leading causes of global mortality and long-term disability, driving the urgent need for accurate and early risk prediction tools. Traditional models such as the Framingham Stroke Risk Score have provided foundational insights into stroke prevention but are constrained by linear assumptions and limited adaptability to complex real-world data. In contrast, machine learning (ML) techniques offer the ability to model non-linear relationships and interactions among diverse clinical and demographic variables, supporting more personalized and flexible risk prediction.MethodsThis study evaluates five supervised ML algorithms, Logistic Regression, Random Forest, Gradient Boosting, Support Vector Machine (SVM), and K-Nearest Neighbours (KNN), using a publicly available dataset from Kaggle. Following class imbalance correction, models were assessed using multiple metrics including accuracy, ROC-AUC, and confusion matrices.ResultsLogistic Regression and Gradient Boosting achieved the highest accuracy (95.11%) and ROC-AUC (0.836), although all models demonstrated poor recall, reflecting challenges in identifying rare stroke cases. Feature importance analysis using the Random Forest model identified age, average glucose level, and BMI as the most influential predictors of stroke, aligning with the Metabolic Syndrome Hypothesis and previous epidemiological findings.DiscussionThese findings underscore both the promise and current limitations of ML in stroke risk prediction and highlight the need for future research leveraging multi-modal datasets and advanced algorithmic strategies to enhance sensitivity and clinical utility.