AUTHOR=Yao Mian-Xuan , Yao Min-Yi , Gu Jia , Gao Ting , Yuan Yi-Mian , Chen Yang-Kun , Liu Yong-Lin 

TITLE=Early heart rate predicts 3-month outcomes in acute ischemic stroke patients receiving intravenous thrombolysis: a machine learning approach

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1668901

DOI=10.3389/fneur.2025.1668901

ISSN=1664-2295

ABSTRACT=BackgroundThe predictive role of early heart rate (HR) dynamics in acute ischemic stroke patients (AIS) receiving intravenous thrombolysis (IVT) remains unclear. This study aimed to evaluate whether HR variability within 24 h post-IVT predicts early neurological deterioration (END) and 3-month functional outcomes using machine learning.MethodsThis retrospective analysis included AIS patients without atrial fibrillation (AF) who received IVT at Dongguan People’s Hospital between January 2017 and December 2022. Hourly HR metrics (mean HR, SD, coefficient of variation [CV]) were analyzed. Primary outcomes were END (≥4-point NIHSS increase within 72 h) and poor 3-month outcomes (mRS ≥ 3). Machine learning models were developed and validated via receiver operating characteristic (ROC) analysis.ResultsAmong 381 patients, logistic regression identified NIHSS on admission (OR = 1.287, p < 0.001), maximum HR (OR = 0.956, p = 0.023), minimum HR (OR = 1.027, p = 0.001), and HR SD (OR = 1.356, p = 0.002) as independent predictors of poor 3-month outcomes. HR CV also showed significance but correlated strongly with SD. A machine learning model integrating onset-to-treatment time, NIHSS, and HR parameters (max/min HR, mean HR, SD) achieved an area under the ROC curve (AUC) of 0.82 for predicting 3-month outcomes. No HR metrics were significantly associated with END.ConclusionIn AIS patients without AF, early HR dynamics—particularly maximum HR, minimum HR, SD, and CV—strongly correlate with 3-month functional outcomes after IVT. The machine learning model demonstrated high predictive accuracy, highlighting the potential of real-time HR monitoring for risk stratification and personalized management in thrombolysis-treated AIS patients.