REVIEW article
Front. Neurol.
Sec. Epilepsy
Cerebellar neuromodulation in drug-resistant epilepsy
- LC
Linbo Chen
- JG
jianing gan
People‘s Hospital of Linshui County, Guangan, China
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Abstract
Drug-resistant epilepsy (DRE) is a major challenge in current clinical practice, and there is an urgent need for new treatment strategies. Studies suggest that the cerebellum holds promise as a key therapeutic target for neuromodulation; however, large-scale randomized controlled trials to validate this remain lacking. Therefore, this article reviews the mechanisms by which the cerebellum is involved in epilepsy treatment and the research progress on various neuromodulation techniques, providing both theoretical and practical grounds for establishing the cerebellum as a new therapeutic target for DRE.
Summary
Keywords
Cerebellum, Drug-resistant epilepsy, Epilepsy, Neuromodulation, therapeutic targets
Received
19 June 2026
Accepted
05 August 2026
Copyright
© 2026 Chen and gan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Linbo Chen
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.