https://www.frontiersin.org/journals/neurology RSS Feed for Frontiers in Neurology | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-14T05:28:26.18+00:00 60 https://www.frontiersin.org/articles/10.3389/fneur.2026.1761459 https://www.frontiersin.org/articles/10.3389/fneur.2026.1761459 2026-05-14T00:00:00Z Review Pierluigi DiotaiutiFrancesco Di SienaMarco PalomboGiulio MarottaElisa CavicchioloPio Alfredo Di ToreStefania Mancone https://www.frontiersin.org/articles/10.3389/fneur.2026.1809677 https://www.frontiersin.org/articles/10.3389/fneur.2026.1809677 2026-05-14T00:00:00Z Systematic Review Dongmin DuShurong WangShuran WangHan SunYi Shan https://www.frontiersin.org/articles/10.3389/fneur.2026.1740742 https://www.frontiersin.org/articles/10.3389/fneur.2026.1740742 2026-05-14T00:00:00Z Systematic Review Jing TanYongyan TangDaobin Han https://www.frontiersin.org/articles/10.3389/fneur.2026.1777478 https://www.frontiersin.org/articles/10.3389/fneur.2026.1777478 2026-05-14T00:00:00Z Original Research Shu KanGege ZhangHua YuHongmei Ding  2) outcome groups.ResultsOf the 20 patients (14 males and 6 females; mean age: 57 years), seizures represented the most prevalent chief complaint at onset (70%). Cognitive impairment was noted as an initial presenting symptom in 45% of patients, whereas its cumulative incidence reached 95% throughout the entire disease course. Pathognomonic faciobrachial dystonic seizures (FBDS) occurred in 40% of cases, and hyponatremia was present in 70% of the cohort. Anti-LGI1 antibodies were detected in 95% (19/20) of serum samples and 90% (18/20) of cerebrospinal fluid (CSF) samples. Notably, 40% of patients exhibited unremarkable cranial MRI findings, and 55% demonstrated normal CSF protein levels upon admission. At the 12-month follow-up, 80% of patients achieved favorable functional recovery. Univariate analysis revealed that advanced age (p = 0.006), prolonged diagnostic delay (p = 0.009), and higher antibody titers in both serum (p = 0.005) and CSF (p = 0.009) were significantly correlated with poor functional outcomes.ConclusionThe high frequency of unremarkable results in initial ancillary investigations, such as MRI and routine CSF analysis, often leads to substantial diagnostic and therapeutic delays in anti-LGI1 encephalitis. Advanced age, diagnostic latency, and high antibody titers are critical predictors of poor prognosis. Early and simultaneous antibody screening in both serum and CSF is essential for narrowing the diagnostic window and optimizing long-term neurological recovery.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1695091 https://www.frontiersin.org/articles/10.3389/fneur.2026.1695091 2026-05-14T00:00:00Z Original Research Wei WangShilin LiuYifan FuXiaoxuan LiMinghao XuXiaochan XuTao Jiang https://www.frontiersin.org/articles/10.3389/fneur.2026.1764551 https://www.frontiersin.org/articles/10.3389/fneur.2026.1764551 2026-05-14T00:00:00Z Original Research Zisheng LiuXidong WuJiaming XuJianyong CaiHuajun BaQun LinJun SunWeizhong Shi https://www.frontiersin.org/articles/10.3389/fneur.2026.1829149 https://www.frontiersin.org/articles/10.3389/fneur.2026.1829149 2026-05-13T00:00:00Z Original Research Yingchao HeShuheng ChenDeshan LiuZheng ZhengYongkun LiYinzhou Wang https://www.frontiersin.org/articles/10.3389/fneur.2026.1821856 https://www.frontiersin.org/articles/10.3389/fneur.2026.1821856 2026-05-13T00:00:00Z Systematic Review Lin HuangLe XieDahua Wu 3 days compared with ≤3 days (OR 2.62 vs. 1.48; p for subgroup difference = 0.03). Further subgroup analyses suggested that the association was consistent across subgroups stratified by study design, geographic region, mean age, sex distribution, diabetes proportion, follow-up duration, and study quality (all p for subgroup differences > 0.05).ConclusionHigher acute GV was associated with increased short-term mortality in patients with SAH. Prolonged glucose monitoring may enhance prognostic value. These findings suggest that acute glucose fluctuations may serve as a risk factor for short-term mortality in patients with SAH.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/search, identifier CRD420261330574.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1792705 https://www.frontiersin.org/articles/10.3389/fneur.2026.1792705 2026-05-13T00:00:00Z Original Research Yangyu HuangYing TanJingwen YanYuzhou Guan 0.83 mg/kg to achieve MM or better status was a predictor of relapse (HR = 1.54, p = 0.033). Sixty-eight (32.5%) withdrew steroids, and PSM showed that steroid withdrawal significantly increased relapse risk versus low-dose maintenance (HR = 1.64, p = 0.009).ConclusionIn this steroid-responsive population, patients requiring a maximum induction dose > 0.83 mg/kg to achieve MM or better status have a significantly higher risk of future relapse. Steroid withdrawal is associated with a higher relapse risk compared to low-dose maintenance and should be approached with caution.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1776618 https://www.frontiersin.org/articles/10.3389/fneur.2026.1776618 2026-05-13T00:00:00Z Original Research Adnan I. QureshiNived Jayaraj RanjiniDavid CohenShahhan SpallAkash RoyChristy N. CassarlyRenee H. MartinWilliam J. PowersChun Shing Kwok https://www.frontiersin.org/articles/10.3389/fneur.2026.1788639 https://www.frontiersin.org/articles/10.3389/fneur.2026.1788639 2026-05-13T00:00:00Z Original Research Shiyu ZhouYiwan FangHaoxin JiHuazheng YanJianxiong GaoHezuo Lü https://www.frontiersin.org/articles/10.3389/fneur.2026.1754777 https://www.frontiersin.org/articles/10.3389/fneur.2026.1754777 2026-05-13T00:00:00Z Systematic Review Chunyue XuHan YangWenyue CaiQun LiuMingjia ZhangHongge ZuoJianbang SuJingqi ShuZhenhua Xu https://www.frontiersin.org/articles/10.3389/fneur.2026.1802799 https://www.frontiersin.org/articles/10.3389/fneur.2026.1802799 2026-05-13T00:00:00Z Original Research Lingyu ShengZiyao ZhangGuiyun CuiJie Xiang https://www.frontiersin.org/articles/10.3389/fneur.2026.1776595 https://www.frontiersin.org/articles/10.3389/fneur.2026.1776595 2026-05-13T00:00:00Z Systematic Review Jiayu YouHang ZhouQianshuo LiuXingqiang Li 90 days to 12 months), EVT significantly improved functional excellence [modified Rankin Scale 0–1; risk ratio (RR) = 3.84, 95% confidence interval (CI) = 2.35–6.28; p < 0.001], functional independence (modified Rankin Scale 0–2; RR = 3.13, 95%CI = 2.01–4.86; p < 0.001), and independent ambulation (modified Rankin Scale 0–3; RR = 2.01, 95%CI = 1.52–2.67; p < 0.001) in patients with anterior circulation large ischemic infarcts; mortality was not significantly different between groups (RR = 0.90, 95%CI = 0.78–1.05; p = 0.19). EVT also reduced the risk of death or dependency (modified Rankin Scale 4–6; RR = 0.78, 95%CI = 0.73–0.84; p < 0.001). Long-term follow-up revealed more significant prognostic improvements with EVT compared with short-term follow-up.ConclusionIn AIS patients with anterior circulation LVO-related large ischemic infarcts, EVT plus MC yielded statistically significant long-term functional improvements compared with MC alone. EVT’s benefits were amplified with longer follow-up and were more pronounced in patients with shorter onset time and smaller infarct volume.Systmatic review registraionhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420251144703, CRD420251144703.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1789311 https://www.frontiersin.org/articles/10.3389/fneur.2026.1789311 2026-05-13T00:00:00Z Original Research Juan WeiQiaowei LiXing LiuLingling JiCuiyun Zhang 6 h. Multivariable logistic regression identified independent influencing factors.ResultsThe pre-hospital delay rate was 54.44%. Significantly, factors from multiple levels of the Health Ecology Model were independently associated with delay: Lower stroke awareness(OR = 5.414, 95% CI 2.291–12.794), Perception of symptom severity (OR = 31.798, 95% CI 13.119–77.077), limb weakness /numbness (OR = 3.661, 95% CI 1.221–10.979), lower health literacy (OR = 1.064, 95% CI 1.041–1.088), poorer family function (OR = 1.545, 95% CI 1.138–2.097), lower social support (OR = 1.466, 95% CI 1.322–1.627), and stroke onset during the night (OR = 0.160, 95% CI 0.064–0.401),which increased the odds of delay.ConclusionPre-hospital delay is highly prevalent and is influenced by a complex interplay of factors across individual, family, and systemic levels, as elucidated by the Health Ecology Model. Our findings highlight the critical need to move beyond patient education alone and implement integrated, multi-level interventions. Public health campaigns should target both patients and their families to improve symptom recognition and health literacy. Concurrently, healthcare systems must be optimized, for instance by addressing barriers to after-hours care and strengthening pre-hospital pathways to ensure rapid triage to comprehensive stroke centers, ultimately improving access to timely revascularization therapies.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1834087 https://www.frontiersin.org/articles/10.3389/fneur.2026.1834087 2026-05-13T00:00:00Z Original Research Ahmad A. AlharbiMohammad B. AlkhodairAbdulaziz A. AlbalwiHamad S. Al AmerAkram M. AbdelrahmanFaisal M. AlzuhairNawaf N. AlsulamiAbrar H. Alhazmi https://www.frontiersin.org/articles/10.3389/fneur.2026.1820825 https://www.frontiersin.org/articles/10.3389/fneur.2026.1820825 2026-05-13T00:00:00Z Original Research Sezgin KehayaErdi Şensöz https://www.frontiersin.org/articles/10.3389/fneur.2026.1808282 https://www.frontiersin.org/articles/10.3389/fneur.2026.1808282 2026-05-13T00:00:00Z Original Research Xusheng LiAhmad Nazrun ShuidMohd Fairudz Mohd MiswanXiao ZhangWenbo GuDonghui CaoJungang WangZiyang JiangHaifeng Yuan https://www.frontiersin.org/articles/10.3389/fneur.2026.1827022 https://www.frontiersin.org/articles/10.3389/fneur.2026.1827022 2026-05-13T00:00:00Z Original Research Hideyo KasaiTaro YasumotoShota KosugeAyako OsanaiKeita MizumaAkinori FutamuraTakeshi KurodaKenjiro OnoHidetomo Murakami https://www.frontiersin.org/articles/10.3389/fneur.2026.1784653 https://www.frontiersin.org/articles/10.3389/fneur.2026.1784653 2026-05-13T00:00:00Z Systematic Review Linshan JiangZhongyin ZhangXiaojun LiuYanxing JiangQianqian Mou