https://www.frontiersin.org/journals/neurology RSS Feed for Frontiers in Neurology | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-13T08:15:27.801+00:00 60 https://www.frontiersin.org/articles/10.3389/fneur.2026.1789311 https://www.frontiersin.org/articles/10.3389/fneur.2026.1789311 2026-05-13T00:00:00Z Original Research Juan WeiQiaowei LiXing LiuLingling JiCuiyun Zhang 6 h. Multivariable logistic regression identified independent influencing factors.ResultsThe pre-hospital delay rate was 54.44%. Significantly, factors from multiple levels of the Health Ecology Model were independently associated with delay: Lower stroke awareness(OR = 5.414, 95% CI 2.291–12.794), Perception of symptom severity (OR = 31.798, 95% CI 13.119–77.077), limb weakness /numbness (OR = 3.661, 95% CI 1.221–10.979), lower health literacy (OR = 1.064, 95% CI 1.041–1.088), poorer family function (OR = 1.545, 95% CI 1.138–2.097), lower social support (OR = 1.466, 95% CI 1.322–1.627), and stroke onset during the night (OR = 0.160, 95% CI 0.064–0.401),which increased the odds of delay.ConclusionPre-hospital delay is highly prevalent and is influenced by a complex interplay of factors across individual, family, and systemic levels, as elucidated by the Health Ecology Model. Our findings highlight the critical need to move beyond patient education alone and implement integrated, multi-level interventions. Public health campaigns should target both patients and their families to improve symptom recognition and health literacy. Concurrently, healthcare systems must be optimized, for instance by addressing barriers to after-hours care and strengthening pre-hospital pathways to ensure rapid triage to comprehensive stroke centers, ultimately improving access to timely revascularization therapies.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1829149 https://www.frontiersin.org/articles/10.3389/fneur.2026.1829149 2026-05-13T00:00:00Z Original Research Yingchao HeShuheng ChenDeshan LiuZheng ZhengYongkun LiYinzhou Wang https://www.frontiersin.org/articles/10.3389/fneur.2026.1754777 https://www.frontiersin.org/articles/10.3389/fneur.2026.1754777 2026-05-13T00:00:00Z Systematic Review Chunyue XuHan YangWenyue CaiQun LiuMingjia ZhangHongge ZuoJianbang SuJingqi ShuZhenhua Xu https://www.frontiersin.org/articles/10.3389/fneur.2026.1808282 https://www.frontiersin.org/articles/10.3389/fneur.2026.1808282 2026-05-13T00:00:00Z Original Research Xusheng LiAhmad Nazrun ShuidMohd Fairudz Mohd MiswanXiao ZhangWenbo GuDonghui CaoJungang WangZiyang JiangHaifeng Yuan https://www.frontiersin.org/articles/10.3389/fneur.2026.1792705 https://www.frontiersin.org/articles/10.3389/fneur.2026.1792705 2026-05-13T00:00:00Z Original Research Yangyu HuangYing TanJingwen YanYuzhou Guan 0.83 mg/kg to achieve MM or better status was a predictor of relapse (HR = 1.54, p = 0.033). Sixty-eight (32.5%) withdrew steroids, and PSM showed that steroid withdrawal significantly increased relapse risk versus low-dose maintenance (HR = 1.64, p = 0.009).ConclusionIn this steroid-responsive population, patients requiring a maximum induction dose > 0.83 mg/kg to achieve MM or better status have a significantly higher risk of future relapse. Steroid withdrawal is associated with a higher relapse risk compared to low-dose maintenance and should be approached with caution.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1821856 https://www.frontiersin.org/articles/10.3389/fneur.2026.1821856 2026-05-13T00:00:00Z Systematic Review Lin HuangLe XieDahua Wu 3 days compared with ≤3 days (OR 2.62 vs. 1.48; p for subgroup difference = 0.03). Further subgroup analyses suggested that the association was consistent across subgroups stratified by study design, geographic region, mean age, sex distribution, diabetes proportion, follow-up duration, and study quality (all p for subgroup differences > 0.05).ConclusionHigher acute GV was associated with increased short-term mortality in patients with SAH. Prolonged glucose monitoring may enhance prognostic value. These findings suggest that acute glucose fluctuations may serve as a risk factor for short-term mortality in patients with SAH.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/search, identifier CRD420261330574.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1827022 https://www.frontiersin.org/articles/10.3389/fneur.2026.1827022 2026-05-13T00:00:00Z Original Research Hideyo KasaiTaro YasumotoShota KosugeAyako OsanaiKeita MizumaAkinori FutamuraTakeshi KurodaKenjiro OnoHidetomo Murakami https://www.frontiersin.org/articles/10.3389/fneur.2026.1820825 https://www.frontiersin.org/articles/10.3389/fneur.2026.1820825 2026-05-13T00:00:00Z Original Research Sezgin KehayaErdi Şensöz https://www.frontiersin.org/articles/10.3389/fneur.2026.1802799 https://www.frontiersin.org/articles/10.3389/fneur.2026.1802799 2026-05-13T00:00:00Z Original Research Lingyu ShengZiyao ZhangGuiyun CuiJie Xiang https://www.frontiersin.org/articles/10.3389/fneur.2026.1788639 https://www.frontiersin.org/articles/10.3389/fneur.2026.1788639 2026-05-13T00:00:00Z Original Research Shiyu ZhouYiwan FangHaoxin JiHuazheng YanJianxiong GaoHezuo Lü https://www.frontiersin.org/articles/10.3389/fneur.2026.1826373 https://www.frontiersin.org/articles/10.3389/fneur.2026.1826373 2026-05-12T00:00:00Z Original Research Peng ZhangLiangyun SunLiangxue Wang  0.05). Although the incidence of sICH was numerically higher in the Tenecteplase group, the difference was not statistically significant (p = 0.449). Workflow efficiency, measured by door-to-needle time, was similar between groups.ConclusionTenecteplase exhibits a non-inferior efficacy and safety profile compared to Alteplase in a real-world setting characterized by high baseline stroke severity. These findings support Tenecteplase as a practical and effective therapeutic alternative for routine AIS management.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1825718 https://www.frontiersin.org/articles/10.3389/fneur.2026.1825718 2026-05-12T00:00:00Z Original Research Zhi WangWei WangRui TangShilun GaoYubao ZhuTianxiang GuXiaojing JiangEnyi Shi https://www.frontiersin.org/articles/10.3389/fneur.2026.1820005 https://www.frontiersin.org/articles/10.3389/fneur.2026.1820005 2026-05-12T00:00:00Z Review Ga-Young KimWon-Suk SungEun-Jung Kim https://www.frontiersin.org/articles/10.3389/fneur.2026.1706424 https://www.frontiersin.org/articles/10.3389/fneur.2026.1706424 2026-05-12T00:00:00Z Systematic Review Ningyu WeiHongyu LuYuan Cheng https://www.frontiersin.org/articles/10.3389/fneur.2026.1814482 https://www.frontiersin.org/articles/10.3389/fneur.2026.1814482 2026-05-12T00:00:00Z Original Research Rui LuFeng LiMenghuan YanXiaoxian DengXintian LiuQi ChenHaojie ZhangFeng ZhuXuan ZhengGangcheng Zhang https://www.frontiersin.org/articles/10.3389/fneur.2026.1838518 https://www.frontiersin.org/articles/10.3389/fneur.2026.1838518 2026-05-12T00:00:00Z Editorial Xuan HeSiyu ZhouYe LiLiang WangJiannan Li https://www.frontiersin.org/articles/10.3389/fneur.2026.1857435 https://www.frontiersin.org/articles/10.3389/fneur.2026.1857435 2026-05-12T00:00:00Z Correction Xue GongJing GanXiaoqian WangJun ChenXueyi RaoJianjun WangYajun ShenJia Zhang https://www.frontiersin.org/articles/10.3389/fneur.2026.1803502 https://www.frontiersin.org/articles/10.3389/fneur.2026.1803502 2026-05-12T00:00:00Z Original Research Jinrong WangHong HuangKeyu DaiZicong LiLiguo ZhangHua Liu https://www.frontiersin.org/articles/10.3389/fneur.2026.1677483 https://www.frontiersin.org/articles/10.3389/fneur.2026.1677483 2026-05-12T00:00:00Z Original Research Stephanie ReichlSybille RoschkaBernadette EinhäuplDanae GötzeChristopher SchössowAndreas BenderThomas Platz https://www.frontiersin.org/articles/10.3389/fneur.2026.1733609 https://www.frontiersin.org/articles/10.3389/fneur.2026.1733609 2026-05-11T00:00:00Z Original Research Edouard DucoffreYannick BleyenheuftMassimo PentaMerlin SomvilleZélie RosselliGeoffroy SaussezYves VandermeerenCarlyne Arnould