https://www.frontiersin.org/journals/neurology/sections/stroke RSS Feed for Stroke section in the Frontiers in Neurology journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-09T17:58:48.483+00:00 60 https://www.frontiersin.org/articles/10.3389/fneur.2026.1808174 https://www.frontiersin.org/articles/10.3389/fneur.2026.1808174 2026-05-08T00:00:00Z Brief Research Report Shinsuke MuraokaKaito KimuraIssei TakeuchiShunsaku GotoMasahiro NishihoriTakashi IzumiRyuta Saito https://www.frontiersin.org/articles/10.3389/fneur.2026.1810507 https://www.frontiersin.org/articles/10.3389/fneur.2026.1810507 2026-05-08T00:00:00Z Original Research Yutong HouShuna YangYue LiWenli HuLei Yang https://www.frontiersin.org/articles/10.3389/fneur.2026.1757307 https://www.frontiersin.org/articles/10.3389/fneur.2026.1757307 2026-05-08T00:00:00Z Original Research Haoyu WangWei NiYao ChenHaifang YuYarong He https://www.frontiersin.org/articles/10.3389/fneur.2026.1821579 https://www.frontiersin.org/articles/10.3389/fneur.2026.1821579 2026-05-08T00:00:00Z Original Research Sávio BatistaMateus Damiani MonteiroFadi NahabPedro Nascimento MartinsJaydevsinh N. DoliaTheja YelamMichael FrankelJohn OshinskiGhada A. MohamedJason AllenDiogo C. Haussen https://www.frontiersin.org/articles/10.3389/fneur.2026.1792925 https://www.frontiersin.org/articles/10.3389/fneur.2026.1792925 2026-05-08T00:00:00Z Original Research Felix MüllerArda CivelekLuis WeitbrechtLukas BaduraKai Helge SchmidtFlorian SchlotterPhilipp LurzStavros V. KonstantinidesKarsten KellerKlaus GröschelMarianne HahnTimo Uphaus 5) to Find AF” (AS5F) score was explored for atrial fibrillation (AF) risk assessment.MethodsThis retrospective single-center study included consecutive patients with ischemic stroke or TIA and PFO treated at the University Medical Centre Mainz (2015–2022). TIA was defined clinically by symptom resolution within 24 h due to inconsistent MRI availability. Follow-up was performed via standardized telephone interviews ≥12 months after the index event. Subgroup analyses compared patients by PFO closure status, AF diagnosis, recurrent ischemic events, and age ≥60 years.ResultsAmong 188 patients, 62 underwent PFO closure. These patients were younger, had fewer cardiovascular risk factors, and more often exhibited embolic PFO features (PASCAL). The RoPE score was higher in the closure group (6.0 ± 1.7 vs. 4.1 ± 1.5; p < 0.001). The AS5F score was lower in closure patients but higher in those with AF (p < 0.001). In patients ≥60 years, higher AS5F scores were associated with AF (cut-off 3.8; p = 0.026). Despite greater comorbidity, over half of patients with recurrent events remained classified as cryptogenic.ConclusionThese findings reflect real-world decision-making in PFO-associated stroke and highlight limitations of score-based approaches. While RoPE and PASCAL remain central, structured AF risk assessment may provide additional value, particularly in older patients. The high rate of cryptogenic recurrence suggests that the role of PFO may be underestimated in clinical practice. Given the moderate sample size, especially in elderly patients, these results should be considered exploratory and hypothesis-generating.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1788829 https://www.frontiersin.org/articles/10.3389/fneur.2026.1788829 2026-05-07T00:00:00Z Systematic Review Johanna C. M. SchilderMaurits H. J. HoonhorstRalph de VriesGert Kwakkel https://www.frontiersin.org/articles/10.3389/fneur.2026.1658764 https://www.frontiersin.org/articles/10.3389/fneur.2026.1658764 2026-05-07T00:00:00Z Clinical Trial Wai Kwong TangHanna LuThomas Wai Hong LeungKenneth Nai Kuen FongSelina Kit Yi ChanVivien Wei Jun Liew  0.05).ConclusionWe found no evidence that the use of tDCS improves PSF. Further research is needed to explore the potential of this non-invasive brain stimulation method for the treatment of PSF.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT04238260; https://www.chictr.org.cn/, identifier ChiCTR2100052515.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1833721 https://www.frontiersin.org/articles/10.3389/fneur.2026.1833721 2026-05-07T00:00:00Z General Commentary Hao ChenYichun Zou https://www.frontiersin.org/articles/10.3389/fneur.2026.1834657 https://www.frontiersin.org/articles/10.3389/fneur.2026.1834657 2026-05-05T00:00:00Z Original Research Keqiong YanLan YeMei WuJun Yang https://www.frontiersin.org/articles/10.3389/fneur.2026.1804177 https://www.frontiersin.org/articles/10.3389/fneur.2026.1804177 2026-05-04T00:00:00Z Original Research Anqi LuoSujani BandelaGretchel Gealogo-BrownMark P. GoldbergAndrew SlusherReza BehrouzAlibay JafarliSiddarth PrasadDaiWai OlsonMaria DenbowMehari GebreyohannsAsmiet TechanChethan P. Venkatasubba RaoJane A. AndersonBarbara KimmelAnette OvalleMichele PattersonSean I. SavitzSalvador Cruz-FloresSteven WarachLee Birnbaum https://www.frontiersin.org/articles/10.3389/fneur.2026.1817627 https://www.frontiersin.org/articles/10.3389/fneur.2026.1817627 2026-05-04T00:00:00Z Original Research Li XuFan LiuXiaoran ZhangZhe XieWenwei ZouMengchao WangZhongwen ZhiYufeng LiuLiandong Zhao 0.05). The RCS curve showed nonlinear associations between CMI (p for nonlinear = 0.048), MCMI (p for nonlinear <0.001) and END. The areas under the curves of CMI and MCMI were 0.643 (95% Confidence interval (CI): 0.601–0.682) and 0.665 (95%CI: 0.625–0.704), respectively.ConclusionOur study showed that CMI and MCMI at admission were independently associated with END in AIS patients, which could be helpful for early risk stratification of stroke patients.]]> https://www.frontiersin.org/articles/10.3389/fneur.2026.1773323 https://www.frontiersin.org/articles/10.3389/fneur.2026.1773323 2026-05-04T00:00:00Z Original Research Mayila AbuduainiXinli XiongGang LiTianrui ZhuYaling ZhengQi WangZhengyu HuangYue Zhang https://www.frontiersin.org/articles/10.3389/fneur.2026.1823316 https://www.frontiersin.org/articles/10.3389/fneur.2026.1823316 2026-05-04T00:00:00Z Systematic Review Jiaqi JiaoJiawei ZhangXuehui LanJunhong GuoShaoshuai Wang https://www.frontiersin.org/articles/10.3389/fneur.2026.1786103 https://www.frontiersin.org/articles/10.3389/fneur.2026.1786103 2026-05-04T00:00:00Z Systematic Review Shuaijing WanXiaolu LiuWenjing JiangZesen LiZhexuan YanWeibo LiYu Yin https://www.frontiersin.org/articles/10.3389/fneur.2026.1807072 https://www.frontiersin.org/articles/10.3389/fneur.2026.1807072 2026-04-30T00:00:00Z Systematic Review Yuxue TongSongmei CaoJingjing WangYuan QinJingxi LinZhen FangJing Qiu https://www.frontiersin.org/articles/10.3389/fneur.2026.1819703 https://www.frontiersin.org/articles/10.3389/fneur.2026.1819703 2026-04-30T00:00:00Z Original Research Sisi JiangWeinv FanYunqin WuXiaoxia LiuDa LiOu ZhangXiaofeng XieFeiyu ChenYindan Yao https://www.frontiersin.org/articles/10.3389/fneur.2026.1721769 https://www.frontiersin.org/articles/10.3389/fneur.2026.1721769 2026-04-30T00:00:00Z Original Research Bader N. AlharbiFahad K. AlsharefFahad K. AldossaryHamad A. AlsaggabiSaleh A. AlhaweryHussain S. AlderaMoeber M. MahzariNasser AlotaibiBijesh YadavNaif M. Alhawiti https://www.frontiersin.org/articles/10.3389/fneur.2026.1711050 https://www.frontiersin.org/articles/10.3389/fneur.2026.1711050 2026-04-29T00:00:00Z Perspective Ivonne SalinasLaura VelaShabnam SantosAriel MoncayoKevin MorenoAuki GuaillasRamiro F. DiazAndrés Caicedo https://www.frontiersin.org/articles/10.3389/fneur.2026.1773324 https://www.frontiersin.org/articles/10.3389/fneur.2026.1773324 2026-04-29T00:00:00Z Systematic Review Xianrong FengYujiao TangBaojia WangZhiqing Liu https://www.frontiersin.org/articles/10.3389/fneur.2026.1796559 https://www.frontiersin.org/articles/10.3389/fneur.2026.1796559 2026-04-29T00:00:00Z Original Research Xiaochan XiaoHuodan YuHaichuan ZhouWenjian LuYanping ZengQianxue Chen