AUTHOR=Bahari-Javan Sanaz , Sananbenesi Farahnaz , Fischer Andre 

TITLE=Histone-acetylation: a link between Alzheimer's disease and post-traumatic stress disorder?

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 8 - 2014

YEAR=2014

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2014.00160

DOI=10.3389/fnins.2014.00160

ISSN=1662-453X

ABSTRACT=The orchestration of gene-expression programs is essential for cellular homeostasis. Epigenetic processes provide to the cell a lkey mechanism that allows the regulation of gene-expression networks in response to environmental stimuli. Recently epigenetic mechanisms such as histone-modifications have been implicated with cognitive function and altered epigenome plasticity has been linked to the pathogenesis of neurodegenerative and neuropsychiatric diseases. Thus, key regulators of epigenetic gene-expression have emerged as novel drug targets for brain diseases. Numerous recent review articles discuss in detail the current findings of epigenetic processes in brain diseases. T  he aim of this article is not to give yet another comprehensive overview of the field but to specifically address the question why the same epigenetic therapies that target histone-acetylation may be suitable to treat seemingly different diseases such as Alzheimer’s disease post-traumatic stress disorder.