AUTHOR=Tsetsos Fotis , Padmanabhuni Shanmukha S. , Alexander John , Karagiannidis Iordanis , Tsifintaris Margaritis , Topaloudi Apostolia , Mantzaris Dimitrios , Georgitsi Marianthi , Drineas Petros , Paschou Peristera TITLE=Meta-Analysis of Tourette Syndrome and Attention Deficit Hyperactivity Disorder Provides Support for a Shared Genetic Basis JOURNAL=Frontiers in Neuroscience VOLUME=Volume 10 - 2016 YEAR=2016 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2016.00340 DOI=10.3389/fnins.2016.00340 ISSN=1662-453X ABSTRACT=
Gilles de la Tourette Sydrome (TS) is a childhood onset neurodevelopmental disorder, characterized phenotypically by the presence of multiple motor and vocal tics. It is often accompanied by multiple psychiatric comorbidities, with Attention Deficit/Hyperactivity Disorder (ADHD) among the most common. The extensive co-occurrence of the two disorders suggests a shared genetic background. A major step toward the elucidation of the genetic architecture of TS was undertaken by the first TS Genome-wide Association Study (GWAS) reporting 552 SNPs that were moderately associated with TS (