AUTHOR=Morello Giovanna , Spampinato Antonio Gianmaria , Conforti Francesca Luisa , Cavallaro Sebastiano 

TITLE=Taxonomy Meets Neurology, the Case of Amyotrophic Lateral Sclerosis

JOURNAL=Frontiers in Neuroscience

VOLUME=12

YEAR=2018

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2018.00673

DOI=10.3389/fnins.2018.00673

ISSN=1662-453X

ABSTRACT=<p>Recent landmark publications from our research group outline a transformative approach to defining, studying and treating amyotrophic lateral sclerosis (ALS). Rather than approaching ALS as a single entity, we advocate targeting therapies to distinct “clusters” of patients based on their specific genomic and molecular features. Our findings point to the existence of a molecular taxonomy for ALS, bringing us a step closer to the establishment of a precision medicine approach in neurology practice.</p>