AUTHOR=Zhang Jun-Fang , Zhang Yu-Lei , Wu Yun-Cheng 

TITLE=The Role of Sirt1 in Ischemic Stroke: Pathogenesis and Therapeutic Strategies

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 12 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2018.00833

DOI=10.3389/fnins.2018.00833

ISSN=1662-453X

ABSTRACT=Silent mating-type information regulation 2 homolog 1 (Sirt1)，a nicotine adenine dinucleotide (NAD+)-dependent enzymes，is well known in playing a part in longevity. Ischemic stroke is a major neurological disorder and a leading cause of death and disability worldwide. Recently, many studies have been focused on the role of Sirt1 in ischemic stroke. A plenty of studies consider Sirt1 as a protective factor and investigate the signaling pathways involved in the process under ischemic stress. However, whether upregulation of Sirt1 improves stroke outcome is still controversy. In this review, we will discuss the role and mechanisms of Sirt1 in the setting of ischemic stroke.