AUTHOR=Wang Nan , Zhang Ying , Xu Li , Jin Shuilin 

TITLE=Relationship Between Alzheimer’s Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 12 - 2018

YEAR=2019

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2018.01026

DOI=10.3389/fnins.2018.01026

ISSN=1662-453X

ABSTRACT=Alzheimer's disease (AD) is the most prevalent form of dementia worldwide and many studies have discussed the relationship between immune system and AD pathogenesis. Here, the mendelian randomization study of differencially expressed genes based on microarray data were performed. And 9519 target genes of hippocampus in 146 subjects (73 AD cases and 73 controls) from 4 microarray data sets were compiled and differentially expressed genes with p<1.0E-4   were selected to explore the pathways analysis. The results indicated that the differentially expressed genes are significantly enriched in the neurodiseases as well as the immune system pathways.