AUTHOR=Ndayisaba Alain , Kaindlstorfer Christine , Wenning Gregor K. 

TITLE=Iron in Neurodegeneration – Cause or Consequence?

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 13 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.00180

DOI=10.3389/fnins.2019.00180

ISSN=1662-453X

ABSTRACT=Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions. Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron overlad in the basal ganglia. High iron levels and iron related pathogenic triggers have also been implicated in sporadic neurodegenerative diseases including Friedreich´s ataxia, Alzheimer’s disease (AD), Parkinson’s disease (PD) and multiple system atrophy (MSA). Iron induced  dyshomeostasis within vulnerable brain regions is still insufficiently understood.
This review summarizes major pathophysiological mechanisms of neurodegeneration and establishes a connection to iron dyshomeostasis aiming to determine the role of iron in disease pathogenesis.